- Tegoprazan, a Novel Potassium-Competitive Acid Blocker to Control Gastric Acid Secretion and Motility
2017/11/27 by Nobuyuki Takahashi, Yukinori Take · 28 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #ATPase #Biochemistry #Biology #Chemistry #Endocrinology #Enzyme #Gastric acid #Gastroesophageal reflux and treatments #Helicobacter pylori-related gastroenterology studies #Histamine #IC50 #In vitro #Internal medicine #Ion Transport and Channel Regulation #Medicine #Motility #Oral administration #Pentagastrin #Pharmacology #Potassium #Stomach
- Determination of half-maximal inhibitory concentration using biosensor-based protein interaction analysis
2016/06/27 by Senem Aykul, Erik Martinez-Hackert, Erik Martı́nez-Hackert · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Antagonist #Biochemistry #Biology #Biophysics #Biotin and Related Studies #Chemistry #Computational biology #Drug #Drug discovery #HER2/EGFR in Cancer Research #IC50 #In vitro #Ligand (biochemistry) #Materials science #Nanotechnology #Pharmacology #Potency #Receptor #Surface plasmon resonance #TGF-β signaling in diseases
- MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition
2015/09/26 by Matthew Fell, Matthew J. Fell, Christian Mirescu +20 · 34 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Alzheimer's disease research and treatments #Biochemistry #Biology #Chemistry #Dephosphorylation #Gene #Genetics #IC50 #In vitro #In vivo #Kinase #LRRK2 #Mutation #Parkinson's Disease Mechanisms and Treatments #Pharmacology #Phosphatase #Phosphorylation #Plant Gene Expression Analysis
- Major Active Components in Grapefruit, Orange, and Apple Juices Responsible for OATP2B1-Mediated Drug Interactions
2013/06/21 by Yoshiyuki Shirasaka, Megumi Shichiri, Takanori Mori +2 · 8 citations
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Biochanin A #Biochemistry #Chemistry #Chromatography #Daidzein #Drug Transport and Resistance Mechanisms #Drug-Induced Hepatotoxicity and Protection #Flavonoid #Genistein #Grapefruit juice #Hesperetin #Hesperidin #IC50 #In vitro #Internal medicine #Medicine #Naringenin #Naringin #Pharmacogenetics and Drug Metabolism #Pharmacokinetics #Pharmacology #Phloretin #Quercetin
- Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity
2010/11/01 by Kathleen Knights, Arduino A. Mangoni, John O. Miners · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Biochemistry #Biology #Context (archaeology) #Eicosanoids and Hypertension Pharmacology #IC50 #In vitro #Inflammatory mediators and NSAID effects #Internal medicine #Medicine #Pharmacogenetics and Drug Metabolism #Pharmacology #Proportional hazards model #Prostacyclin #Toxicity
- E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities
2009/08/15 by Masaki Goto, Jesse Chow, Jesse C. Chow +15 · 14 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · Medicine · #Biochemistry #Biology #Chemistry #Cytokine Signaling Pathways and Interactions #Extracellular #IC50 #Immunology #In vitro #Kinase #MAPK/ERK pathway #Metabolite #Microsome #NF-κB Signaling Pathways #Protein kinase A #Psoriasis: Treatment and Pathogenesis #Stereochemistry #Tumor necrosis factor alpha
- Structure−Activity Relationship Analysis of Novel Derivatives of Narciclasine (an Amaryllidaceae Isocarbostyril Derivative) as Potential Anticancer Agents
2009/01/26 by Laurent Ingrassia, Florence Lefranc, Janique Dewelle +9 · 1 citation
Chemistry · Pharmacology, Toxicology and Pharmaceutics · Medicine · #Chemical synthesis and alkaloids #Alkaloids: synthesis and pharmacology #Cholinesterase and Neurodegenerative Diseases #Chemistry #Apoptosis #In vivo #Cytotoxicity #In vitro #Cytotoxic T cell #Stereochemistry #Cancer cell #Derivative (finance) #IC50 #Pharmacology #Growth inhibition #Cancer #Biochemistry #Biology
- Anti-tumor Promoting Activity of Bufadienolides from Kalanchoe pinnata and K. daigremontiana × butiflora
2001/01/01 by Unang Supratman, Tomoyuki Fujita, Kohki Akiyama +5 · 1 citation
Biochemistry, Genetics and Molecular Biology · Materials Science · Chemistry · Medicine · #Phytochemical Studies and Bioactivities #Phytochemistry and Bioactive Compounds #Natural product bioactivities and synthesis #Kalanchoe #Crassulaceae #Raji cell #Biology #IC50 #Traditional medicine #Biochemistry #Chemistry #In vitro #Botany #Medicine
- In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents
1992/09/01 by Roberto Cedillo‐Rivera, R. Cedillo-Rivera, O. Munoz · 16 citations
Chemistry · Immunology and Microbiology · Medicine · #Albendazole #Amoebic Infections and Treatments #Antibiotics #Benzimidazole #Biochemistry #Biology #Chemistry #Chromatography #Ciprofloxacin #Giardia lamblia #IC50 #In vitro #Mebendazole #Metronidazole #Microbiology #Minimum inhibitory concentration #Nalidixic acid #Nitrofuran #Ornidazole #Parasitic Infections and Diagnostics #Parasitic infections in humans and animals #Pharmacology #Tinidazole
- Mitochondrial effects of the guanidino group-containing cytostatic drugs, m-iodobenzylguanidine and methylglyoxal bis (guanylhydrazone)
1991/07/01 by C. Loesberg, Cornelia Loesberg, Henny Van Rooij +3 · 3 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Alcoholism and Thiamine Deficiency #Biochemistry #Biology #Cancer, Hypoxia, and Metabolism #Cell culture #Chemistry #Endocrinology #Enzyme #Glycolysis #IC50 #In vitro #Internal medicine #Medicine #Metabolism #Metabolism and Genetic Disorders #Methylglyoxal #Mitochondrion #Molecular biology #Neuroblastoma #Polyamine #Putrescine #Respiration #Respiratory chain #Spermine