Mitochondrial effects of the guanidino group-containing cytostatic drugs, m-iodobenzylguanidine and methylglyoxal bis (guanylhydrazone)

1991/07/01 by Cornelia Loesberg, C. Loesberg, Henny Van Rooij +3 · 3 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Alcoholism and Thiamine Deficiency #Biochemistry #Biology #Cancer, Hypoxia, and Metabolism #Cell culture #Chemistry #Endocrinology #Enzyme #Glycolysis #IC50 #In vitro #Internal medicine #Medicine #Metabolism #Metabolism and Genetic Disorders #Methylglyoxal #Mitochondrion #Molecular biology #Neuroblastoma #Polyamine #Putrescine #Respiration #Respiratory chain #Spermine

paper · doi:10.1016/0006-2952(91)90038-7

openalex publication_date 1991/07/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/26

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• Guanidino-containing drugs in cancer chemotherapy: biochemical and clinical pharmacology33Abbreviations: MIBG, m-iodobenzylguanidine; MGBG, methylglyoxal bis(guanylhydrazone); MIBA, m-iodobenzylamine; BG, benzylguanidine; NE, norepinephrine; GBG, glyoxal bis(guanylhydrazone); EGBG, ethylglyoxal bis(guanylhydrazone); MGBCP, methylglyoxal bis(cyclopentylamidinohydrazone); ODC, ornithine decarboxylase; and SAMDC, S-adenosylmethionine decarboxylase.
• De novo design and synthesis of dipyridopurinone derivatives as visible-light photocatalysts in productive guanylation reactions. [europepmc]
• Guanylation Reactions for the Rational Design of Cancer Therapeutic Agents. [europepmc]