- Organic Anion Transporting Polypeptide–Mediated Hepatic Uptake of Glucuronide Metabolites of Androgens
2020/06/25 by Cindy Yanfei Li, Anshul Gupta, Zsuzsanna Gáborik +2 · 17 citations
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Androgen #Androsterone #Biochemistry #Biology #Chemistry #Dihydrotestosterone #Drug Transport and Resistance Mechanisms #Endocrinology #Etiocholanolone #Gene #Glucuronidation #Hormonal and reproductive studies #Hormone #In vitro #Internal medicine #Microsome #Organic anion transporter 1 #Organic anion-transporting polypeptide #Pharmacogenetics and Drug Metabolism #Steroid #Transporter
- Mechanistic Basis of Cabotegravir–Glucuronide Disposition in Humans
2019/06/07 by Mitesh Patel, H. Christian Eberl, Andrea J. Wolf +5 · 8 citations
Chemistry · Medicine · #ATP-binding cassette transporter #Biochemistry #Biology #Chemistry #Drug Transport and Resistance Mechanisms #Enterohepatic circulation #Enzyme #Excretion #Glucuronidation #Glucuronide #HIV/AIDS drug development and treatment #Hepatitis C virus research #Internal medicine #Medicine #Metabolism #Metabolite #Microsome #Multidrug resistance-associated protein 2 #Organic anion transporter 1 #Pharmacology #Transporter
- The inhibitory effects of β-caryophyllene, β-caryophyllene oxide and α-humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro
2017/10/23 by Linh Thuy Nguyen, Zuzana Myslivečková, Barbora Szotáková +8 · 66 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Biochemistry #Biology #Biotechnology #CYP3A #Chemistry #Drug #Drug-Induced Hepatotoxicity and Protection #Enzyme #In vivo #Microsome #Pharmacogenetics and Drug Metabolism #Pharmacology #Plant Toxicity and Pharmacological Properties
- The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes
2017/04/27 by Ahmed A. Albassam, Reginald F. Frye, John S. Markowitz · 27 citations
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Antioxidant #Biochemistry #Biology #Chemistry #Chromatography #Drug-Induced Hepatotoxicity and Protection #Enzyme #Flavonoid #Microsome #Milk Thistle #Pharmacogenetics and Drug Metabolism #Pharmacology #Silibinin #Silybum marianum #Silymarin and Mushroom Poisoning #Taxifolin
- PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA
2008/09/07 by Chunna Yu, Shanshan Ye, Hongying Sun +5 · 69 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Biochemistry #Biology #CYP3A #CYP3A4 #Chemistry #Constitutive androstane receptor #Cytochrome P450 #Enzyme #Gene #Gene expression #In vitro #Medicine #Microsome #Nuclear receptor #Pharmacogenetics and Drug Metabolism #Pharmacology #Plant biochemistry and biosynthesis #Pregnane X receptor #Reporter gene #Salvia miltiorrhiza #Traditional Chinese Medicine Analysis #Traditional Chinese medicine #Transcription factor
- Expression of ovarian microsomal epoxide hydrolase and glutathione S-transferase during onset of VCD-induced ovotoxicity in B6C3F1 mice
2008/03/03 by Aileen F. Keating, I. Glenn Sipes, I.G. Sipes +1 · 36 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Andrology #Antral follicle #Biochemistry #Biology #Birth, Development, and Health #Chemistry #Endocrinology #Enzyme #Epoxide hydrolase #Follicle #Glutathione #Glutathione S-transferase #Glutathione Transferases and Polymorphisms #Hair follicle #Internal medicine #Medicine #Microsomal epoxide hydrolase #Microsome #Ovarian follicle #Ovary #Reproductive Biology and Fertility
- Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions
2006/11/09 by R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan · 459 citations
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Biochemistry #Biology #Chemistry #Clearance #Cytochrome P450 #Drug #Drug Transport and Resistance Mechanisms #Drug metabolism #Enzyme #In vitro #In vivo #Medicine #Microsome #Pharmacogenetics and Drug Metabolism #Pharmacokinetics #Pharmacological Effects and Toxicity Studies #Pharmacology #Physiologically based pharmacokinetic modelling #S9 fraction
- ω-Oxidation of Very Long-chain Fatty Acids in Human Liver Microsomes
2006/03/18 by Robert‐Jan Sanders, Robert-Jan Sanders, Rob Ofman +5 · 56 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Biochemistry #Chain (unit) #Chemistry #Eicosanoids and Hypertension Pharmacology #Enzyme #Metabolism and Genetic Disorders #Metabolomics and Mass Spectrometry Studies #Microsome
- Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity
2005/01/01 by María Eugenia Letelier, Ana María Lepe, Mario Faúndez +5 · 247 citations
Chemistry · Environmental Science · Medicine · Nursing · #Antioxidant #Biochemistry #Chemistry #Copper #Copper toxicity #Enzyme #Glutathione #Heavy Metal Exposure and Toxicity #Iron Metabolism and Disorders #Membrane #Metabolism #Microsome #Organic chemistry #Oxidative phosphorylation #Reactive oxygen species #Thiol #Toxicity #Trace Elements in Health
- The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties
2002/12/01 by Rupert P. Austin, Patrick Barton, Scott L. Cockroft +2 · 410 citations
Chemistry · Computer Science · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Biochemistry #Chemistry #Chromatography #Computational Drug Discovery Methods #Drug Transport and Resistance Mechanisms #In vitro #Lipophilicity #Microsoma #Microsome #Partition coefficient #Pharmacogenetics and Drug Metabolism
- N-Glucuronidation of Some 4-Arylalkyl-1H-Imidazoles by Rat, Dog, and Human Liver Microsomes
2002/03/01 by Sanna Kaivosaari, Jarmo S. Salonen, Jyrki Taskinen · 21 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Biochemistry #Carcinogens and Genotoxicity Assessment #Chemistry #Drug Transport and Resistance Mechanisms #Endocrinology #Glucuronidation #Imidazole #In vitro #Medetomidine #Microsoma #Microsome #Pharmacogenetics and Drug Metabolism #Stereochemistry
- Delayed ontogenesis of CYP1A2 in the human liver
1998/02/01 by Michelle Sonnier, Thierry Cresteil · 229 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Antibody #Biochemistry #Biology #CYP1A2 #CYP2E1 #CYP3A #CYP3A4 #Cytochrome P450 #Demethylation #Eicosanoids and Hypertension Pharmacology #Endocrinology #Enzyme #Fetus #Gene #Gene expression #Immunology #Internal medicine #Medicine #Metabolism and Genetic Disorders #Microsome #Molecular biology #Pharmacogenetics and Drug Metabolism #Polyclonal antibodies
- Biochemical and morphological studies of ammonium perfluorooctanoate-induced hepatomegaly and peroxisome proliferation
1987/08/01 by Timothy P. Pastoor, Ki Poong Lee, Marie A. Perri +1 · 90 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Biochemistry #Biology #Cancer, Hypoxia, and Metabolism #Carnitine #Chemistry #Endocrinology #Endoplasmic reticulum #Enzyme #Glutathione #Internal medicine #Medicine #Metabolism and Genetic Disorders #Microsome #Mitochondrion #Peroxisome #Peroxisome Proliferator-Activated Receptors