The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

2002/12/01 by Rupert P. Austin, Patrick Barton, Scott L. Cockroft +2 · 410 citations
Chemistry · Computer Science · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Biochemistry #Chemistry #Chromatography #Computational Drug Discovery Methods #Drug Transport and Resistance Mechanisms #In vitro #Lipophilicity #Microsoma #Microsome #Partition coefficient #Pharmacogenetics and Drug Metabolism

paper · doi:10.1124/dmd.30.12.1497

published in Drug Metabolism and Disposition 30(12), 1497-1503 (American Society for Pharmacology and Experimental Therapeutics)

openalex publication_date 2002/12/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

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