THE BINDING OF DRUGS TO HEPATOCYTES AND ITS RELATIONSHIP TO PHYSICOCHEMICAL PROPERTIES

2004/12/23 by Rupert P. Austin, Patrick Barton, Sarfraz Mohmed +1 · 174 citations
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Binding site #Biochemistry #Biology #Chemistry #Dialysis #Drug Transport and Resistance Mechanisms #Drug-Induced Hepatotoxicity and Protection #Enzyme #Hepatocyte #In vitro #Internal medicine #Kinetics #Lipophilicity #Metabolism #Microsome #Pharmacogenetics and Drug Metabolism #Pharmacology #Plasma protein binding #Receptor #Receptor–ligand kinetics

paper · doi:10.1124/dmd.104.002436

published in Drug Metabolism and Disposition 33(3), 419-425 (American Society for Pharmacology and Experimental Therapeutics)

openalex publication_date 2004/12/23 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/27

Citations

• The Influence of Nonspecific Microsomal Binding on Apparent Intrinsic Clearance, and Its Prediction from Physicochemical Properties

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