Major Active Components in Grapefruit, Orange, and Apple Juices Responsible for OATP2B1-Mediated Drug Interactions

2013/06/21 by Yoshiyuki Shirasaka, Megumi Shichiri, Takanori Mori +2 · 8 citations
Medicine · Pharmacology, Toxicology and Pharmaceutics · #Drug Transport and Resistance Mechanisms #Pharmacogenetics and Drug Metabolism #Drug-Induced Hepatotoxicity and Protection

paper · doi:10.1002/jps.23653

Citations

• Fruit juices inhibit organic anion transporting polypeptide–mediated drug uptake to decrease the oral availability of fexofenadine
• Naringin is a Major and Selective Clinical Inhibitor of Organic Anion-Transporting Polypeptide 1A2 (OATP1A2) in Grapefruit Juice

Cited by

• Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice. [europepmc]
• Does consumption of red grapefruit juice alter naringenin concentrations in milk produced by breastfeeding mothers? [europepmc]
• Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles. [europepmc]
• Stimulatory effect on the transport mediated by organic anion transporting polypeptide 2B1. [europepmc]
• Potential Risk of Food-Drug Interactions: Citrus Polymethoxyflavones and Flavanones as Inhibitors of the Organic Anion Transporting Polypeptides (OATP) 1B1, 1B3, and 2B1. [europepmc]
• Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review. [europepmc]
• Flavonoids and Furanocoumarins Involved in Drug Interactions. [europepmc]
• Regional absorption of talinolol mediated by intestinal transporters: insights from PBPK modeling analysis. [europepmc]