- Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex
2026/01/08 by Christopher J. Lupton, Charles Bayly-Jones, Shuqi Dong +12 · 2 voices · 1 citation
Biochemistry, Genetics and Molecular Biology · #Adenosine triphosphate #Amino acid #Cellular transport and secretion #Docking (animal) #GTP' #GTPase #Guanosine #Guanosine triphosphate #Lysosome #Microtubule and mitosis dynamics #PI3K/AKT/mTOR signaling in cancer #Triphosphatase #mTORC1
- Microtubule dynamics are defined by conformations and stability of clustered protofilaments
2025/05/29 by Maksim Kalutskii, Helmut Grubmüller, Vladimir A. Volkov +1 · 1 voice · 7 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Biochemistry #Biology #Biophysics #Cell #Cell biology #Cellular Mechanics and Interactions #Chemistry #Crystallography #Cytoskeleton #Enzyme #GTP' #Microtubule #Microtubule and mitosis dynamics #Microtubule polymerization #Polymer #Polymerization #Protist diversity and phylogeny #Tubulin
- Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C
2024/12/06 by Anna E. Maciag, James P. Stice, Bin Wang +32 · 1 voice · 4 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · #Biochemistry #Chemistry #Covalent bond #Dual (grammatical number) #Enzyme #Enzyme Structure and Function #GTP' #Metabolism, Diabetes, and Cancer #Organic chemistry #Protein Kinase Regulation and GTPase Signaling
- Structure-Function Relationships of the G Domain, a Canonical Switch Motif
2011/03/03 by Alfred Wittinghofer, Ingrid R. Vetter · 7 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · Mathematics · #Biochemistry #Biology #Biophysics #Chemistry #Combinatorics #Computational biology #Enzyme Structure and Function #GTP' #GTPase #Gene #Mathematics #Metabolism, Diabetes, and Cancer #Nucleotide #Protein Kinase Regulation and GTPase Signaling #Protein structure #Stereochemistry #Topology (electrical circuits)
- Comparative analysis of the ATP‐binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C‐terminal ATP‐binding site
2003/05/12 by Csaba So˝ti, Csaba So ̋ti, Ákos Vermes +3 · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Binding site #Biochemistry #Biology #Chemistry #Cyclic nucleotide-binding domain #Enzyme #GTP' #Heat shock proteins research #Nucleotide
- Analysis of the Small GTPase Gene Superfamily of Arabidopsis
2003/03/01 by Vanessa Vernoud, Amy C. Horton, Zhenbiao Yang +1 · 34 citations
Biochemistry, Genetics and Molecular Biology · #Arabidopsis #Biochemistry #Biology #Cell biology #Cellular transport and secretion #G protein #GTP' #GTP-binding protein regulators #GTPase #GTPase-activating protein #Gene #Genetics #Plant Reproductive Biology #Protein Kinase Regulation and GTPase Signaling #Rab #Ras superfamily #Signal transduction
- An isoform–specific interaction of the membrane anchors affects mammalian adenylyl cyclase type V activity
2001/01/01 by Thomas Seebacher, Jürgen U. Linder, Joachim E. Schultz · 8 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Adenylyl cyclase #Biochemistry #Biology #Cell biology #Cellular transport and secretion #Chemistry #Enzyme #GTP' #Gene #Gene isoform #Lipid Membrane Structure and Behavior #Membrane #Membrane protein #Receptor #Receptor Mechanisms and Signaling #Transmembrane domain #Transmembrane protein
- On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins
1986/09/01 by Yoshihisa Kurachi, Toshiaki Nakajima, TsuNeaki Sugimoto +1 · 19 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Acetylcholine #Adenosine #Biochemistry #Biology #Biophysics #Cardiac electrophysiology and arrhythmias #Chemistry #Dissociation constant #G protein #GTP' #Intracellular #Ion channel regulation and function #Medicine #Muscarinic acetylcholine receptor #Neuroscience and Neural Engineering #Patch clamp #Pertussis toxin #Pharmacology #Population #Receptor
- Synergistic effects of 5′-nucleotides on rat taste responses to various amino acids
1986/03/01 by Kiyonori Yoshii, Chizuko Yokouchi, Kenzo Kurihara · 9 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · Nursing · #Amino acid #Biochemical Analysis and Sensing Techniques #Biochemistry #Chemistry #Enzyme #GTP' #Nucleotide #Olfactory and Sensory Function Studies #RNA and protein synthesis mechanisms #Stereochemistry #Taste
- Mechanism of action and selectivity of acyclovir
1982/07/01 by Gertrude B. Elion · 26 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Immunology and Microbiology · Medicine · #Aciclovir #Biochemistry #Biology #Chemistry #DNA #DNA polymerase #Enzyme #GTP' #Guanosine triphosphate #Herpes simplex virus #Herpesviridae #Herpesvirus Infections and Treatments #Nucleoside #Polymerase #Primer (cosmetics) #Thymidine #Thymidine kinase #Toxin Mechanisms and Immunotoxins #Vero cell #Viral disease #Virology #Virus #Virus-based gene therapy research
- Microtubule Formation in vitro in Solutions Containing Low Calcium Concentrations
1972/09/22 by Richard C. Weisenberg · 5 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #14-3-3 protein interactions #Adenosine #Adenosine triphosphate #Biochemistry #Biology #Biophysics #Calcium #Cancer Treatment and Pharmacology #Cell biology #Chemistry #Enzyme #GTP' #Guanosine #Guanosine triphosphate #In vitro #In vivo #Magnesium #Microtubule #Microtubule and mitosis dynamics #Organic chemistry #Polymerization #Tubulin