Nalân Utku

1. Prevention of Acute Allograft Rejection by Antibody Targeting of TIRC7, a Novel T Cell Membrane Protein
   1998/10/01 by Nalân Utku, Thomas Heinemann, Stefan G. Tullius +18 · 57 citations
   Immunology and Microbiology · Medicine · #Antibody #Biochemistry #Biology #Cancer research #Cell #Cell biology #Cytokine #Immune Cell Function and Interaction #Immune system #Immunology #Immunotherapy and Immune Responses #In vitro #In vivo #Internal medicine #Medicine #Molecular biology #Secretion #T-cell and B-cell Immunology #Transplantation
2. Genomic Organization of the Gene Coding for TIRC7, a Novel Membrane Protein Essential for T Cell Activation
   1999/05/01 by Thomas Heinemann, Grit-Carsta Bulwin, Jeffrey Randall +8 · 57 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Cell Adhesion Molecules Research #Coding region #Exon #Gene #Genetics #Genome #Genomic organization #Glycosylation and Glycoproteins Research #Intron #Locus (genetics) #Molecular biology #RNA modifications and cancer #Tandem exon duplication #Transmembrane protein
3. Monoclonal Antibody Specific for TIRC7 Induces Donor-specific Anergy and Prevents Rejection of Cardiac Allografts in Mice
   2004/04/01 by Yusuke Kumamoto, Antje Tomschegg, Fatima Bennai-Sanfourche +8 · 22 citations
   Immunology and Microbiology · Medicine · #T-cell and B-cell Immunology #Immune Cell Function and Interaction #Immune Response and Inflammation #Medicine #Monoclonal antibody #Immunology #Immune system #Transplantation #T cell #Tumor necrosis factor alpha #Lymphocyte #Ex vivo #IL-2 receptor #In vivo #Mixed lymphocyte reaction #Interleukin 2 #T lymphocyte #Cancer research #Antibody #Biology #Internal medicine
4. Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice
   2006/02/16 by Nalân Utku, Thomas Heinemann, Michael B. Winter +6 · 18 citations
   Medicine · Immunology and Microbiology · #Cytokine Signaling Pathways and Interactions #Cell Adhesion Molecules Research #Immune Response and Inflammation #Rheumatoid arthritis #Monoclonal antibody #Immunology #Arthritis #Antibody #T cell #Antigen #Medicine #Immune system
5. TIRC7 Deficiency Causes In Vitro and In Vivo Augmentation of T and B Cell Activation and Cytokine Response
   2004/08/01 by Nalân Utku, Anke Boerner, Antje Tomschegg +6 · 27 citations
   Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Chemistry · Medicine · #NF-κB Signaling Pathways #Neutrophil, Myeloperoxidase and Oxidative Mechanisms #Immune Response and Inflammation #In vivo #Cytokine #In vitro #Immunology #Cell biology #Chemistry #Medicine #Biology #Biochemistry #Biotechnology
6. TIRC7 is induced in rejected human kidneys and anti-TIRC7 mAb with FK506 prolongs survival of kidney allografts in rats
   2006/10/12 by Yusuke Kumamoto, Akihiko Tamura, Hans‐Dieter Volk +5 · 8 citations
   Immunology and Microbiology · Medicine · #Antibody #Biology #Biopsy #Calcineurin #Cytokine #Immune system #Immunohistochemistry #Immunology #In vivo #Internal medicine #Kidney #Kidney transplantation #Medicine #Monoclonal antibody #Pathology #Peptidase Inhibition and Analysis #Pharmacology #Renal Transplantation Outcomes and Treatments #T-cell and B-cell Immunology #Tacrolimus #Transplantation
7. HLA-DR Alpha 2 Mediates Negative Signalling via Binding to Tirc7 Leading to Anti-Inflammatory and Apoptotic Effects in Lymphocytes In Vitro and In Vivo
   2008/02/12 by Grit-Carsta Bulwin, Stephanie Wälter, Mirko Schlawinsky +10 · 12 citations
   Immunology and Microbiology · Chemistry · #Immune Cell Function and Interaction #T-cell and B-cell Immunology #Immunotherapy and Immune Responses #Cell biology #CD8 #Proinflammatory cytokine #T-cell receptor #Biology #Cytotoxic T cell #T cell #Apoptosis #ZAP70 #Molecular biology #Chemistry #In vitro #Immunology #Antigen #Immune system #Inflammation #Biochemistry
8. TIRC7 Pathway as a Target for Preventing Allograft Rejection
   2005/01/01 by Akihiko Tamura, Edgar L. Milford, Nalân Utku · 6 citations
   Immunology and Microbiology · Medicine · #Immune Response and Inflammation #T-cell and B-cell Immunology #Neutrophil, Myeloperoxidase and Oxidative Mechanisms #Immune system #Monoclonal antibody #Transplant rejection #Immunology #Calcineurin #Antibody #Biology #T cell #Cytotoxic T cell #Antigen #Transplantation #Cell biology #Medicine
9. TIRC7 Inhibits T Cell Proliferation by Modulation of CTLA-4 Expression
   2006/11/01 by Grit-Carsta Bulwin, Thomas Heinemann, Volker Bugge +13 · 23 citations
   Immunology and Microbiology · Chemistry · #T-cell and B-cell Immunology #Immunotherapy and Immune Responses #Immune Response and Inflammation #CTLA-4 #Cell biology #T cell #Cell growth #Chemistry #Cytotoxic T cell #Intracellular #Biology #Cytokine #Immunology #Immune system #In vitro #Biochemistry