Prevention of Acute Allograft Rejection by Antibody Targeting of TIRC7, a Novel T Cell Membrane Protein

1998/10/01 by Nalân Utku, Thomas Heinemann, Stefan G. Tullius +18 · 15 citations
Immunology and Microbiology · Medicine · #Antibody #Biochemistry #Biology #Cancer research #Cell #Cell biology #Cytokine #Immune Cell Function and Interaction #Immune system #Immunology #Immunotherapy and Immune Responses #In vitro #In vivo #Internal medicine #Medicine #Molecular biology #Secretion #T-cell and B-cell Immunology #Transplantation

paper · pdf · doi:10.1016/s1074-7613(00)80634-2

crossref issued 1998/10/01 · crossref published 1998/10/01 · crossref published-print 1998/10/01 · openalex publication_date 1998/10/01 · crossref created 2004/06/17 · crossref deposited 2024/01/13 · openalex created_date 2025/10/10 · crossref indexed 2026/04/23 · openalex updated_date 2026/08/01

Citations

• The mechanism of action of cyclosporin A and FK506
• Molecular Cloning and Characterization of a Putative Novel Human Osteoclast-Specific 116-kDa Vacuolar Proton Pump Subunit
• Functional diversity of helper T lymphocytes

Cited by

• CTLA-4 trafficking and surface expression
• Monitoring of intragraft and peripheral blood TIRC7 expression as a diagnostic tool for acute cardiac rejection in humans
• TIRC7 is induced in rejected human kidneys and anti-TIRC7 mAb with FK506 prolongs survival of kidney allografts in rats
• Cytokine and TIRC7 mRNA expression during acute rejection in cardiac allograft recipients
• Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis
• Monoclonal Antibody Specific for TIRC7 Induces Donor-specific Anergy and Prevents Rejection of Cardiac Allografts in Mice
• Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice
• Prediction of Graft-Versus-Host Disease in Humans by Donor Gene-Expression Profiling
• HLA-DR Alpha 2 Mediates Negative Signalling via Binding to Tirc7 Leading to Anti-Inflammatory and Apoptotic Effects in Lymphocytes In Vitro and In Vivo
• TIRC7 and HLA-DR axis contributes to inflammation in multiple sclerosis
• Molecular Profile of Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis
• TIRC7 Deficiency Causes In Vitro and In Vivo Augmentation of T and B Cell Activation and Cytokine Response
• TIRC7 Inhibits T Cell Proliferation by Modulation of CTLA-4 Expression
• Characterization of IL-10-Secreting T Cells Derived from Regulatory CD4+CD25+ Cells by the TIRC7 Surface Marker
• TCIRG1 [wikipedia]