Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice

2006/02/16 by Nalân Utku, Thomas Heinemann, Michael B. Winter +6 · 18 citations
Medicine · Immunology and Microbiology · #Cytokine Signaling Pathways and Interactions #Cell Adhesion Molecules Research #Immune Response and Inflammation #Rheumatoid arthritis #Monoclonal antibody #Immunology #Arthritis #Antibody #T cell #Antigen #Medicine #Immune system

paper · pdf · doi:10.1111/j.1365-2249.2006.03044.x

published in Clinical & Experimental Immunology 144(1), 142-151 (Oxford University Press)

openalex publication_date 2006/02/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Abstract

TIRC7 is a cell surface molecule which is expressed in T and B lymphocytes and negatively regulates their function. Anti-TIRC7 specific monoclonal antibody (mAb) inhibited T cell memory response to recall antigens. Up-regulation of TIRC7 on lymphocytes from joint tissue of patients with Rheumatoid Arthritis (RA) and mice with collagen induced arthritis (CIA) suggested TIRC7 as a novel target to promote anti-inflammatory reaction. Anti-TIRC7 mAb administration significantly inhibited the induction and progression of CIA and the anti-collagen IgG1 and IgG2a antibody response. Combination therapy of anti-TIRC7 mAb and soluble TNF-alpha receptor demonstrated an increased inhibitory effect over the single compounds on CIA. The results demonstrate the therapeutic potential of TIRC7 targeting with mAb in diseases associated with exaggerated T and B cell responses.

Citations

• Monitoring of intragraft and peripheral blood TIRC7 expression as a diagnostic tool for acute cardiac rejection in humans
• Monoclonal Antibody Specific for TIRC7 Induces Donor-specific Anergy and Prevents Rejection of Cardiac Allografts in Mice
• Prevention of Acute Allograft Rejection by Antibody Targeting of TIRC7, a Novel T Cell Membrane Protein
• Genomic Organization of the Gene Coding for TIRC7, a Novel Membrane Protein Essential for T Cell Activation

Cited by

• HLA-DR Alpha 2 Mediates Negative Signalling via Binding to Tirc7 Leading to Anti-Inflammatory and Apoptotic Effects in Lymphocytes In Vitro and In Vivo
• TIRC7 and HLA-DR axis contributes to inflammation in multiple sclerosis
• TCIRG1 [wikipedia]