Genomic Organization of the Gene Coding for TIRC7, a Novel Membrane Protein Essential for T Cell Activation

1999/05/01 by Thomas Heinemann, Grit-Carsta Bulwin, Jeffrey Randall +8 · 57 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Cell Adhesion Molecules Research #Coding region #Exon #Gene #Genetics #Genome #Genomic organization #Glycosylation and Glycoproteins Research #Intron #Locus (genetics) #Molecular biology #RNA modifications and cancer #Tandem exon duplication #Transmembrane protein

paper · doi:10.1006/geno.1999.5751

published in Genomics 57(3), 398-406 (Elsevier BV)

crossref issued 1999/05/01 · crossref published 1999/05/01 · crossref published-print 1999/05/01 · openalex publication_date 1999/05/01 · crossref created 2002/10/07 · openalex created_date 2025/10/10 · crossref deposited 2025/10/11 · crossref indexed 2026/02/24 · openalex updated_date 2026/08/01

Citations

• Molecular Cloning and Characterization of a Putative Novel Human Osteoclast-Specific 116-kDa Vacuolar Proton Pump Subunit
• Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1

Cited by

• TCIRG1-dependent recessive osteopetrosis: Mutation analysis, functional identification of the splicing defects, andin vitro rescue by U1 snRNA
• Monitoring of intragraft and peripheral blood TIRC7 expression as a diagnostic tool for acute cardiac rejection in humans
• TIRC7 is induced in rejected human kidneys and anti-TIRC7 mAb with FK506 prolongs survival of kidney allografts in rats
• Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis
• Mutations in the a3 subunit of the vacuolar H+-ATPase cause infantile malignant osteopetrosis
• Monoclonal Antibody Specific for TIRC7 Induces Donor-specific Anergy and Prevents Rejection of Cardiac Allografts in Mice
• Antibody targeting of TIRC7 results in significant therapeutic effects on collagen-induced arthritis in mice
• TIRC7 Deficiency Causes In Vitro and In Vivo Augmentation of T and B Cell Activation and Cytokine Response
• TCIRG1 [wikipedia]