- Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β
2026/01/16 by Kanako Shinno, Yuri Miura, Koichi Iijima +2 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Amyotrophic Lateral Sclerosis Research #Autophagy #Autophagy in Disease and Therapy #Axon #Axoplasmic transport #Mitochondrial Function and Pathology #Mitochondrion #Neurodegeneration #Phosphorylation #Protein subunit #Proteostasis
- Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system
2025/09/15 by Tal Levin, Hector Garcia‐Seisdedos, Arseniy Lobov +6 · 1 voice · 4 citations
Biochemistry, Genetics and Molecular Biology · #Biochemical and Molecular Research #Cellular compartment #Colocalization #Intracellular #Protein aggregation #Protein folding #Proteome #Proteomics #Proteostasis #RNA modifications and cancer #Ubiquitin and proteasome pathways
- Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability
2024/05/01 by Adi Shimshon, Karin Dahan, Mor Israel-Gueta +6 · 10 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biochemistry #Biology #Cell biology #Degron #Enzyme #Peptidase Inhibition and Analysis #Protease #Protease and Inhibitor Mechanisms #Proteases #Proteolysis #Proteostasis #Ubiquitin #Ubiquitin and proteasome pathways #Ubiquitin ligase #Ubiquitin-Protein Ligases
- ATF6 protects against protein misfolding during cardiac hypertrophy
2024/02/23 by Christoph P. Hofmann, Christoph Hofmann, Marjan Aghajani +15 · 7 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #ATF6 #Advanced Glycation End Products research #Biology #Cardiac hypertrophy #Cell biology #Chemistry #Endocrinology #Endoplasmic Reticulum Stress and Disease #Endoplasmic reticulum #Genetics, Aging, and Longevity in Model Organisms #Internal medicine #Medicine #Muscle hypertrophy #Pressure overload #Protein folding #Proteostasis #Unfolded protein response
- Recent advances in cellular degradation and nuclear control of leaf senescence
2023/07/15 by Lei Pei, Pei Lei, Fei Yu +1 · 13 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Biology #Cell biology #Cellular senescence #Crosstalk #Gene #Genetics #Nutrient sensing #Phenotype #Photosynthetic Processes and Mechanisms #Plant Gene Expression Analysis #Plant Molecular Biology Research #Proteostasis #Senescence #Signal transduction
- Endoplasmic reticulum oxidoreductin 1‐alpha deficiency and activation of protein translation synergistically impair breast tumour resilience
2022/07/19 by Ersilia Varone, Alessandra Decio, Maria Chiara Barbera +5 · 8 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #ATF4 #Biochemistry #Biology #Breast cancer #CHOP #Cancer #Cancer research #Cancer, Hypoxia, and Metabolism #Cell biology #Cellular stress response #Endocrinology #Endoplasmic Reticulum Stress and Disease #Endoplasmic reticulum #Integrated stress response #Internal medicine #Medicine #Messenger RNA #Microbial Inactivation Methods #Proteostasis #Translation (biology) #Triple-negative breast cancer #Unfolded protein response
- A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome
2020/07/01 by Gennaro Napolitano, Chiara Di Malta, Alessandra Esposito +18 · 1 citation
Chemistry · Medicine · #Biology #Birt–Hogg–Dubé syndrome #Cancer research #Cell biology #Chemistry #Folliculin #Gene #Genetics #Mechanistic target of rapamycin #P70-S6 Kinase 1 #PI3K/AKT/mTOR pathway #Phosphorylation #Proteostasis #RHEB #Renal Diseases and Glomerulopathies #Renal cell carcinoma treatment #Signal transduction #TFEB #Transcription factor #Tuberous Sclerosis Complex Research #mTORC1
- Autophagy: cellular and molecular mechanisms
2010/02/03 by D.R. Glick, Danielle Glick, Sandra Barth +1 · 48 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #ATG16L1 #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Calcium signaling and nucleotide metabolism #Cell biology #Disease #Endoplasmic reticulum #Extracellular vesicles in disease #Intracellular #Medicine #Mitochondrion #Mitophagy #Neurodegeneration #Organelle #Programmed cell death #Proteostasis
- Chaperone‐mediated autophagy is defective in mucolipidosis type IV
2008/12/30 by Bhuvarahamurthy Venugopal, B. Venugopal, Nicholas T. Mesires +5 · 27 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Neuroscience · #Autophagy #Biochemistry #Biology #Calcium signaling and nucleotide metabolism #Cell biology #Chaperone (clinical) #Endosome #Enzyme #Intracellular #Ion Channels and Receptors #Lysosomal storage disease #Lysosome #Molecular biology #Mucolipidosis #Plant Molecular Biology Research #Proteostasis #Receptor #Transient receptor potential channel #Transport protein
- A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65
2026/07/27 by Susanne S Steigleder, Susanne S. Steigleder, I Döring +4
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Brefeldin A #Cellular transport and secretion #Endoplasmic reticulum #Golgi apparatus #Hereditary Neurological Disorders #Hippo pathway signaling and YAP/TAZ #Mechanism (biology) #Proteostasis #Secretion #Secretory pathway #Secretory protein #Transport protein #Unfolded protein response