- Neuronal α-synuclein toxicity is the key driver of neurodegeneration in multiple system atrophy
2025/02/04 by James A. Wiseman, James A Wiseman, Glenda M. Halliday +2 · 11 citations
Medicine · Neuroscience · #Alpha-synuclein #Atrophy #Biology #Cell biology #Central nervous system disease #Cytoplasm #Cytoplasmic inclusion #Degenerative disease #Disease #Genetics #Medicine #Neurodegeneration #Neurological diseases and metabolism #Neurological disorders and treatments #Neuroscience #Olivopontocerebellar atrophy #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pathology
- Alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propagation, aggregation, and the formation of inclusions
2024/09/02 by Armin Bayati, Peter S. McPherson · 13 citations
Chemistry · Medicine · #Alpha-synuclein #Alzheimer's disease research and treatments #Autophagy #Biochemistry #Biology #Cell biology #Chemistry #Dementia #Dementia with Lewy bodies #Enzyme #Gene #Lewy body #Lysosomal Storage Disorders Research #Lysosome #Medicine #Mutation #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pathology
- APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer’s disease with Lewy body pathology
2022/04/26 by Yunjung Jin, Fuyao Li, Berkiye Sonoustoun +18 · 25 citations
Medicine · Neuroscience · #Alpha-synuclein #Alzheimer's disease #Alzheimer's disease research and treatments #Apolipoprotein E #Autopsy #Biology #Degenerative disease #Disease #Internal medicine #Lewy body #Medicine #Neurotoxicity #Nuclear Receptors and Signaling #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pathogenesis #Pathology #Toxicity
- Lewy body disease or diseases with Lewy bodies?
2022/01/10 by Kateřina Menšíková, Radoslav Matěj, Carlo Colosimo +13 · 1 citation
Medicine · Neuroscience · #Parkinson's Disease Mechanisms and Treatments #Alzheimer's disease research and treatments #Neurological disorders and treatments #Dementia with Lewy bodies #Synucleinopathies #Lewy body #Disease #Dementia #Parkinson's disease #Neuroscience #Pathological #Medicine #Biology #Pathology #Alpha-synuclein
- Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential
2021/05/12 by Nelson Ferreira, Hjalte Gram, Zachary A. Sorrentino +27 · 29 citations
Chemistry · Medicine · Neuroscience · #Alpha-synuclein #Alzheimer's disease research and treatments #Anatomy #Atrophy #Biology #Chemistry #Disease #Medicine #Neuroscience #Nuclear Receptors and Signaling #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pathology #Strain (injury)
- Review: Clinical, neuropathological and genetic features of Lewy body dementias
2019/04/12 by D. Hansen, Helen Ling, Tammaryn Lashley +2 · 1 citation
Medicine · Neuroscience · Psychology · #Parkinson's Disease Mechanisms and Treatments #Alzheimer's disease research and treatments #Cerebrovascular and genetic disorders #Dementia #Lewy body #Dementia with Lewy bodies #Cerebral amyloid angiopathy #Neuropathology #Pathology #Parkinsonism #Disease #Medicine #Neuroscience #Alpha-synuclein #Neurodegeneration #Pathological #Parkinson's disease #Psychology
- Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies – current issues and future directions
2019/03/20 by Lauren Walker, Leonidas Stefanis, Johannes Attems · 1 citation
Medicine · Neuroscience · Psychology · #Parkinson's Disease Mechanisms and Treatments #Nuclear Receptors and Signaling #Neurological disorders and treatments #Dementia with Lewy bodies #Dementia #Parkinson's disease #Lewy body #Disease #Pathological #Neuroscience #Medicine #Alpha-synuclein #Neuropathology #Synucleinopathies #Pathology #Psychology #Psychiatry
- Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells
2018/11/07 by Claudio Bussi, Javier M. Peralta Ramos, Javier María Peralta Ramos +12 · 26 citations
Medicine · #Alpha-synuclein #Alzheimer's disease research and treatments #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Cell biology #Fibril #Immunology #Inflammation #Microglia #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pathology
- Somatic copy number gains of α-synuclein (SNCA) in Parkinson’s disease and multiple system atrophy brains
2018/05/18 by Katya Mokretar, Daniel Pease, Jan-Willem Taanman +13 · 27 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Alpha-synuclein #Atrophy #Biology #CRISPR and Genetic Engineering #Copy-number variation #Disease #Dopamine #Dopaminergic #Gene #Genetics #Genomic variations and chromosomal abnormalities #Medicine #Neuroscience #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pathology #Somatic cell #Substantia nigra #Synucleinopathies
- Biomarkers for cognitive impairment in Lewy body disorders: Status and relevance for clinical trials
2018/04/01 by Andrew Siderowf, Dag Aarsland, Brit Mollenhauer +2 · 1 citation
Medicine · Psychology · Neuroscience · #Parkinson's Disease Mechanisms and Treatments #Alzheimer's disease research and treatments #Ginkgo biloba and Cashew Applications #Dementia with Lewy bodies #Lewy body #Dementia #Alpha-synuclein #Parkinson's disease #Clinical trial #Medicine #Disease #Movement disorders #Cognitive decline #Pathology #Biomarker #Psychology #Neuroscience #Biology
- Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies
2018/03/01 by Jose‐Alberto Palma, Horacio Kaufmann · 2 citations
Medicine · #Parkinson's Disease Mechanisms and Treatments #Botulinum Toxin and Related Neurological Disorders #Restless Legs Syndrome Research #Medicine #Synucleinopathies #Pure autonomic failure #Dementia with Lewy bodies #Parkinson's disease #Orthostatic vital signs #Intensive care medicine #Disease #Dementia #Internal medicine #Alpha-synuclein
- REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions
2017/11/01 by Erik K. St. Louis, Erik K. St Louis, Bradley F. Boeve · 1 citation
Medicine · Neuroscience · Psychology · #Alpha-synuclein #Dementia #Dementia with Lewy bodies #Disease #Electroencephalography #Eye movement #Internal medicine #Medicine #Neuroscience #Ophthalmology #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Polysomnography #Psychiatry #Psychology #REM sleep behavior disorder #Rapid eye movement sleep #Restless Legs Syndrome Research #Sleep and Wakefulness Research #Synucleinopathies
- The Synucleinopathies: Twenty Years On
2017/03/06 by Michel Goedert, Ross Jakes, Maria Grazia Spillantini · 2 citations
Medicine · Neuroscience · Psychology · #Parkinson's Disease Mechanisms and Treatments #Neurological disorders and treatments #Genetic Neurodegenerative Diseases #Synucleinopathies #Parkinson's disease #Neuroscience #Medicine #Alpha-synuclein #Psychology #Disease #Internal medicine
- The Differential Diagnosis and Treatment of Atypical Parkinsonism
2016/02/05 by Johannes Levin, Alexander Kurz, Thomas Arzberger +2 · 1 citation
Medicine · Neuroscience · Psychology · #Parkinson's Disease Mechanisms and Treatments #Neurological disorders and treatments #Neurological diseases and metabolism #Progressive supranuclear palsy #Dementia with Lewy bodies #Parkinsonism #Corticobasal degeneration #Synucleinopathies #Medicine #Lewy body #Frontotemporal dementia #Dementia #Apraxia #Pathology #Parkinson's disease #Cerebellar ataxia #Atrophy #Neuroscience #Ataxia #Disease #Psychology #Psychiatry #Alpha-synuclein #Aphasia
- Comprehensive treatment of dementia with Lewy bodies
2015/05/28 by Brendon Boot · 2 citations
Medicine · Psychology · #Parkinson's Disease Mechanisms and Treatments #Ginkgo biloba and Cashew Applications #Cholinesterase and Neurodegenerative Diseases #Dementia with Lewy bodies #Rivastigmine #Dementia #Medicine #Lewy body #Synucleinopathies #Parkinson's disease #REM sleep behavior disorder #Parkinsonism #Disease #Psychiatry #Psychology #Intensive care medicine #Donepezil #Internal medicine #Alpha-synuclein
- Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds
2011/03/26 by Mario Caruana, Tobias Högen, Johannes Levin +4 · 25 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Alpha-synuclein #Biochemical and biochemical processes #Biochemistry #Biology #Chemistry #Disease #Dopamine #Dopaminergic #Gene #Ginkgo biloba and Cashew Applications #Internal medicine #Medicine #Missense mutation #Mutation #Neuroscience #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pars compacta #Pathogenesis #Substantia nigra #Synuclein #Synucleinopathies
- Hallucinations in Neurodegenerative Diseases
2011/02/16 by Lothar Burghaus, Carsten Eggers, Lars Timmermann +2 · 1 citation
Medicine · Neuroscience · Psychology · #Parkinson's Disease Mechanisms and Treatments #Botulinum Toxin and Related Neurological Disorders #Hallucinations in medical conditions #Synucleinopathies #Visual Hallucination #Dementia with Lewy bodies #Psychology #Lewy body #Dementia #Disease #Parkinson's disease #Neuroscience #Parkinsonism #Prodromal Stage #Psychiatry #Medicine #Alpha-synuclein #Pathology
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
2010/09/20 by Ashley R. Winslow, Chien-Wen Chen, Chien‐Wen Chen +13 · 36 citations
Medicine · #Alpha-synuclein #Apoptosis #Autophagosome #Autophagy #Autophagy in Disease and Therapy #Biology #Cell biology #Disease #Gene #Gene knockdown #Genetics #Lysosomal Storage Disorders Research #Medicine #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pathology
- The Lipid-binding Domain of Wild Type and Mutant α-Synuclein
2010/07/01 by Elka R. Georgieva, Trudy F. Ramlall, Peter P. Borbat +2 · 25 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Materials Science · Medicine · #Alpha helix #Alpha-synuclein #Biochemistry #Biology #Biophysics #Chemistry #Circular dichroism #Conducting polymers and applications #Crystallography #Electron Spin Resonance Studies #Helix (gastropod) #Membrane #Mutant #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Protein structure #Vesicle
- Lysosomal Degradation of α-Synuclein in Vivo
2010/03/04 by Sally K. Mak, Alison L. McCormack, Amy Manning-Bog +4 · 28 citations
Chemistry · Medicine · #Alpha-synuclein #Alzheimer's disease research and treatments #Autophagy #Biochemistry #Biology #Cell biology #Chemistry #Endosome #Heat shock protein #In vitro #In vivo #Intracellular #LAMP1 #Lysosomal Storage Disorders Research #Lysosome #Medicine #Neurodegeneration #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Parkinsonism #Pathology #Protein aggregation #Protein degradation
- Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells
2008/06/20 by Tereza Vogiatzi, Maria Xilouri, Kostas Vekrellis +1 · 33 citations
Chemistry · Medicine · Neuroscience · #Alpha-synuclein #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Cell biology #Chaperone (clinical) #Chemistry #Gene #Internal medicine #Mutant #Nerve injury and regeneration #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Proteasome #Protein aggregation #Protein degradation #Wild type
- Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein
2006/12/21 by Sovan Sarkar, Janet E. Davies, J. Eric Davies +3 · 35 citations
Chemistry · Medicine · Neuroscience · #Activator (genetics) #Alpha-synuclein #Apoptosis #Autophagy #Autophagy in Disease and Therapy #BAG3 #Biochemistry #Biology #Cell biology #Chemical chaperone #Chemistry #Genetic Neurodegenerative Diseases #Huntingtin #Huntingtin Protein #Mutant #PI3K/AKT/mTOR pathway #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Receptor #Signal transduction #Trehalose
- α-Synuclein Budding Yeast Model: Toxicity Enhanced by Impaired Proteasome and Oxidative Stress
2006/01/01 by Nijee Sharma, Katrina A. Brandis, Sara K. Herrera +6 · 1 citation
Chemistry · Medicine · Neuroscience · #Alpha-synuclein #Alzheimer's disease research and treatments #Biochemistry #Biology #Cell biology #Chemistry #Genetic Neurodegenerative Diseases #Oxidative stress #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Proteasome #Protein aggregation #Saccharomyces cerevisiae #Superoxide dismutase #Synucleinopathies #Yeast
- Hsp70 Reduces α-Synuclein Aggregation and Toxicity
2004/06/01 by Jochen Klucken, Youngah Shin, Eliezer Masliah +2 · 27 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · Neuroscience · #Alpha-synuclein #Biochemistry #Biology #Calpain Protease Function and Regulation #Cell biology #Chemistry #Cytotoxicity #Dementia #Dementia with Lewy bodies #Disease #Gene #Genetic Neurodegenerative Diseases #Genetics #Heat shock protein #Hsp70 #In vitro #In vivo #Medicine #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pathology #Protein aggregation #Toxicity #Transgene
- Ubiquitination of α-Synuclein in Lewy Bodies Is a Pathological Event Not Associated with Impairment of Proteasome Function
2003/11/01 by George K. Tofaris, Azam Razzaq, Bernardino Ghetti +2 · 32 citations
Chemistry · Medicine · Neuroscience · #Alpha-synuclein #Biochemistry #Biology #Cell biology #Chemistry #Dementia #Dementia with Lewy bodies #Disease #Enzyme #Immunohistochemistry #Lewy body #Lysosomal Storage Disorders Research #Medicine #Neurological diseases and metabolism #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pathology #Proteasome #Proteolysis #Synuclein #Synucleinopathies #Ubiquitin
- α-Synuclein Is Degraded by Both Autophagy and the Proteasome
2003/06/29 by Julie L. Webb, Brinda Ravikumar, Jane Atkins +3 · 40 citations
Chemistry · Medicine · Neuroscience · #Alpha-synuclein #Apoptosis #Autophagy #Autophagy in Disease and Therapy #Biochemistry #Biology #Cell biology #Chemistry #Dementia with Lewy bodies #Disease #Dopamine #Dopaminergic #Immunology #Medicine #Nerve injury and regeneration #Neuroscience #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Pathogenesis #Pathology #Proteasome #Substantia nigra #Synuclein
- Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes
1998/04/01 by W. Sean Davidson, Ana Jonas, David F. Clayton +1 · 44 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Alpha-synuclein #Alzheimer's disease research and treatments #Biochemistry #Biology #Biophysics #Cell biology #Cellular transport and secretion #Chemistry #Membrane #Parkinson's Disease Mechanisms and Treatments #Parkinson's disease #Phospholipid #Synuclein #Vesicle