Samuel J. Danishefsky
- Total Synthesis of Baccatin III and Taxol
1996/01/01 by Samuel J. Danishefsky, John J. Masters, Wendy B. Young +9 · 12 citations
Medicine · Chemistry · #Cancer Treatment and Pharmacology #Synthetic Organic Chemistry Methods #Chemical synthesis and alkaloids
- Useful diene for the Diels-Alder reaction
1974/12/01 by Samuel J. Danishefsky, Takeshi Kitahara · 9 citations
Chemical Engineering · Chemistry · #Catalysis and Oxidation Reactions #Asymmetric Synthesis and Catalysis
- Small Molecule Natural Products in the Discovery of Therapeutic Agents: The Synthesis Connection
2006/08/03 by Rebecca M. Wilson, Samuel J. Danishefsky · 7 citations
Medicine · Chemistry · Biochemistry, Genetics and Molecular Biology · #Microbial Natural Products and Biosynthesis #Chemical synthesis and alkaloids #Marine Sponges and Natural Products
- The Total Synthesis of (+)-Migrastatin
2003/04/25 by Christoph Gaul, Jón T. Njardarson, Samuel J. Danishefsky · 7 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Aldehyde #Aldol condensation #Aldol reaction #Alkene #Catalysis #Chemical Synthesis and Analysis #Chemistry #Combinatorial chemistry #Diene #Enantioselective synthesis #Lewis acids and bases #Metathesis #Natural product #Organic chemistry #Ring-closing metathesis #Stereocenter #Stereochemistry #Synthesis and Catalytic Reactions #Synthetic Organic Chemistry Methods #Total synthesis
- Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog
2010/02/15 by Thórdur Óskarsson, Pavel Nagorny, Isaac J. Krauss +8 · 4 citations
Biochemistry, Genetics and Molecular Biology · #Ubiquitin and proteasome pathways #Glycosylation and Glycoproteins Research #Protein Degradation and Inhibitors
- A Potentially Valuable Advance in the Synthesis of Carbohydrate-Based Anticancer Vaccines through Extended Cycloaddition Chemistry
2006/09/09 by Qian Wan, Jiehao Chen, Gong Chen +1 · 7 citations
Chemistry · Biochemistry, Genetics and Molecular Biology · #Click Chemistry and Applications #Carbohydrate Chemistry and Synthesis #Glycosylation and Glycoproteins Research
- Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition
2008/06/20 by Xiaoguang Lei, Samuel J. Danishefsky · 2 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #ATP Synthase and ATPases Research #Bioactive Compounds and Antitumor Agents
- Synthetic studies toward (+)-cortistatin A
2011/10/31 by Zhang Wang, Mingji Dai, Peter K. Park +1 · 2 citations
Chemistry · #Oxidative Organic Chemistry Reactions #Synthesis and Catalytic Reactions #Synthetic Organic Chemistry Methods
- Effects of temperature and concentration in some ring closing metathesis reactions
2003/04/01 by Kana Yamamoto, Kaustav Biswas, Christoph Gaul +1 · 2 citations
Chemistry · Medicine · #Advanced Synthetic Organic Chemistry #Cancer Treatment and Pharmacology #Synthetic Organic Chemistry Methods
- Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin
2011/08/01 by Nicolas Lecomte, Jón T. Njardarson, Pavel Nagorny +5 · 3 citations
Chemistry · Biochemistry, Genetics and Molecular Biology · #Synthesis and biological activity #14-3-3 protein interactions #Cancer therapeutics and mechanisms
- Preparation and D iels– A lder Reaction of a Highly Nucleophilic Diene: trans ‐1‐Methoxy‐3‐Trimethylsiloxy‐1,3‐Butadiene and 5β‐Methoxycyclohexan‐1‐One‐3β,4β‐Dicarboxylic Acid Anhydride
2003/04/28 by Samuel J. Danishefsky, Takeshi Kitahara, P. F. SCHUDA · 1 citation
Chemistry · Biochemistry, Genetics and Molecular Biology · #Asymmetric Synthesis and Catalysis #Steroid Chemistry and Biochemistry #Synthetic Organic Chemistry Methods