2006/08/03 by Rebecca M. Wilson, Samuel J. Danishefsky · 7 citations
Medicine · Chemistry · Biochemistry, Genetics and Molecular Biology · #Microbial Natural Products and Biosynthesis #Chemical synthesis and alkaloids #Marine Sponges and Natural Products
paper · doi:10.1021/jo0610053
openalex publication_date 2006/08/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Natural products have been a rich source of agents of value in medicine. They have also inspired, at various levels, the fashioning of nonnatural agents of pharmaceutical import. Hitherto, these nonnatural derivatives have been primarily synthesized by manipulating the natural product. As a consequence of major innovations in the subscience of synthetic methodology, the capacity of synthesis to deal with molecules of considerable complexity has increased dramatically. In this paper, we show by example some total syntheses which draw from strategy-enabling advances in methodology. Moreover, we show how these capabilities can be used to discover and develop new agents of potential pharmaceutical value without recourse to the natural product itself.