Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition

2008/06/20 by Xiaoguang Lei, Samuel J. Danishefsky · 2 citations
Biochemistry, Genetics and Molecular Biology · Pharmacology, Toxicology and Pharmaceutics · #ATP Synthase and ATPases Research #Bioactive Compounds and Antitumor Agents

paper · doi:10.1002/adsc.200800187

openalex publication_date 2008/06/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/24

Abstract

The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol (5), is described. The key step involves a fragment coupling using "click chemistry." The preliminary biological evaluation of triazole-cycloproparadicicol is also reported.

Citations

• Small Molecule Natural Products in the Discovery of Therapeutic Agents: The Synthesis Connection

Cited by

• Design and synthesis of analogues of natural products
• Diverted total synthesis [wikipedia]