Diverted Total Synthesis Leads to the Generation of Promising Cell-Migration Inhibitors for Treatment of Tumor Metastasis: In vivo and Mechanistic Studies on the Migrastatin Core Ether Analog

2010/02/15 by Thórdur Óskarsson, Pavel Nagorny, Isaac J. Krauss +8 · 4 citations
Biochemistry, Genetics and Molecular Biology · #Ubiquitin and proteasome pathways #Glycosylation and Glycoproteins Research #Protein Degradation and Inhibitors

paper · doi:10.1021/ja9101503

openalex publication_date 2010/02/15 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/01

Abstract

A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.

Citations

• A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization
• The Total Synthesis of (+)-Migrastatin

Cited by

• Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin
• Synthetic studies toward (+)-cortistatin A
• Post-Polyketide Synthase Steps in Iso-migrastatin Biosynthesis, Featuring Tailoring Enzymes with Broad Substrate Specificity
• Diverted total synthesis [wikipedia]

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