A Rapid Esterification by Means of Mixed Anhydride and Its Application to Large-ring Lactonization

1979/07/01 by Junji Inanaga, Kuniko Hirata, Hiroko SAEKI +2 · 10 citations
Chemistry · #Analytical Chemistry and Chromatography #Synthetic Organic Chemistry Methods #Analytical Methods in Pharmaceuticals

paper · doi:10.1246/bcsj.52.1989

openalex publication_date 1979/07/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/23

Abstract

Abstract A rapid and mild esterification method using carboxylic 2,4,6-trichlorobenzoic anhydrides in the presence of 4-dimethylaminopyridine was developed. The method was also successfully applied to the synthesis of large-ring lactones, including Dl-2,4,6-tridemethyl-3-deoxymethynolide.

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