Peter Holmans

1. Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
   2015/10/01 by Bjarni J. Vilhjálmsson, Bjarni J. Vilhjálmsson, Jian Yang +452 · 61 citations
   Biochemistry, Genetics and Molecular Biology · Mathematics · Medicine · #Advanced Causal Inference Techniques #Allele #Artificial intelligence #Bioinformatics and Genomic Networks #Biology #Computer science #Disequilibrium #Genetic Associations and Epidemiology #Genetics #Haplotype #Linkage disequilibrium #Mathematics #Medicine #Pattern recognition (psychology) #Polygenic risk score #Pruning #Sample (material) #Sample size determination #Single-nucleotide polymorphism #Statistics #Thresholding
2. Biological insights from 108 schizophrenia-associated genetic loci
   2014/07/01 by Stephan Ripke, B M Neale, Kai-How Farh +97 · 20 citations
   Biochemistry, Genetics and Molecular Biology · Neuroscience · #Diabetes and associated disorders #Genetic Associations and Epidemiology #Tryptophan and brain disorders
3. New insights into the genetic etiology of Alzheimer’s disease and related dementias
   2022/04/01 by Céline Bellenguez, Fahri Küçükali, Iris E. Jansen +97 · 48 citations
   Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Genetic Associations and Epidemiology #Nutrition, Genetics, and Disease
4. Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
   2021/05/17 by Niamh Mullins, Andreas J. Forstner, Kevin S. O’Connell +97 · 31 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · #Bipolar Disorder and Treatment #Genetic Associations and Epidemiology #Genetics and Neurodevelopmental Disorders
5. Genome-Wide Analysis of Copy Number Variants in Attention Deficit Hyperactivity Disorder: The Role of Rare Variants and Duplications at 15q13.3
   2011/12/30 by Nigel M. Williams, Nigel Williams, Barbara Franke +63 · 31 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · Psychology · #Attention Deficit Hyperactivity Disorder #Attention deficit hyperactivity disorder #Autism Spectrum Disorder Research #Biology #Copy-number variation #Gene #Genetics #Genome #Genome-wide association study #Genomic variations and chromosomal abnormalities #Genotype #Psychiatry #Psychology #Single-nucleotide polymorphism
6. Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease
   2015/07/01 by Jong-Min Lee, Jong‐Min Lee, Vanessa C. Wheeler +39 · 3 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Age of onset #Allele #Biology #Disease #Fungal and yeast genetics research #Gene #Genetic Neurodegenerative Diseases #Genetic association #Genetics #Genome-wide association study #Genotype #Huntington's disease #Internal medicine #Locus (genetics) #Medicine #Mendelian inheritance #Mitochondrial Function and Pathology #Single-nucleotide polymorphism #Trinucleotide repeat expansion
7. A tutorial comparing different covariate balancing methods with an application evaluating the causal effects of substance use treatment programs for adolescents
   2020/10/19 by Andreas Markoulidakis, Khadijeh Taiyari, Markoulidakis, Andreas +11 · 2 citations
   Mathematics · Social Sciences · #Advanced Causal Inference Techniques #Applications (stat.AP) #FOS: Computer and information sciences #Methodology (stat.ME) #Other Statistics (stat.OT) #School Choice and Performance #Statistical Methods and Bayesian Inference #stat.AP #stat.ME #stat.OT
8. Investigating the Contribution of Common Genetic Variants to the Risk and Pathogenesis of ADHD
   2011/12/30 by Evangelia Stergiakouli, Marian Hamshere, Marian L. Hamshere +14 · 28 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · Psychology · #Attention Deficit Hyperactivity Disorder #Bioinformatics #Biology #Gene #Genetic Neurodegenerative Diseases #Genetic variants #Genetics #Genotype #Internal medicine #Medicine #Nicotinic Acetylcholine Receptors Study #Pathogenesis #Psychiatry #Psychology
9. Genetic modifiers of Mendelian disease: Huntington’s disease and the trinucleotide repeat disorders
   2017/07/03 by Peter Holmans, Peter A. Holmans, Thomas H. Massey +1 · 1 citation
   Biochemistry, Genetics and Molecular Biology · Neuroscience · #Genetic Neurodegenerative Diseases #Genetics and Neurodevelopmental Disorders #Mitochondrial Function and Pathology
10. CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset
    2019/08/01 by Jong‐Min Lee, Kevin Correia, Jacob M. Loupe +35 · 2 citations
    Neuroscience · Biochemistry, Genetics and Molecular Biology · #Genetic Neurodegenerative Diseases #Mitochondrial Function and Pathology #DNA Repair Mechanisms
11. Developmental disruption to the cortical transcriptome and synaptosome in a model of SETD1A loss-of-function
    2022/05/05 by Nicholas E. Clifton, Matthew L. Bosworth, Niels Haan +6 · 1 voice · 1 citation
    Biochemistry, Genetics and Molecular Biology · #Epigenetics and DNA Methylation #Genetic Associations and Epidemiology #Genetics and Neurodevelopmental Disorders
12. Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset
    2022/04/01 by Branduff McAllister, Jasmine Donaldson, Caroline S. Binda +31 · 1 citation
    Neuroscience · Biochemistry, Genetics and Molecular Biology · #Genetic Neurodegenerative Diseases #Mitochondrial Function and Pathology #CRISPR and Genetic Engineering
13. Machine learning in Alzheimer’s disease genetics
    2025/07/21 by Matthew Bracher‐Smith, Federico Melograna, Brittany Ulm +97 · 1 voice · 1 citation
    Biochemistry, Genetics and Molecular Biology · #Bioinformatics and Genomic Networks #Gene expression and cancer classification #Genetic Associations and Epidemiology
14. Rare Copy Number Variants Are Associated With Poorer Cognition in Schizophrenia
    2020/12/18 by Leon Hubbard, Elliott Rees, Derek W. Morris +21 · 12 citations
    Biochemistry, Genetics and Molecular Biology · Medicine · Psychology · #Biology #Clinical psychology #Cognition #Copy-number variation #Effects of sleep deprivation on cognitive performance #Gene #Genetic Associations and Epidemiology #Genetics #Genomic variations and chromosomal abnormalities #Positive and Negative Syndrome Scale #Psychiatry #Psychology #Psychosis #Schizophrenia (object-oriented programming) #Schizophrenia research and treatment #Wechsler Adult Intelligence Scale
15. Genetic modifiers of somatic expansion and clinical phenotypes in Huntington’s disease highlight shared and tissue-specific effects
    2025/06/01 by Group 1, Jong-Min Lee, Jong‐Min Lee +43 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Neuroscience · #Genetic Neurodegenerative Diseases #Mitochondrial Function and Pathology #Muscle Physiology and Disorders