Genetic modifiers of somatic expansion and clinical phenotypes in Huntington’s disease highlight shared and tissue-specific effects

2025/06/01 by Group 1, Jong-Min Lee, Zachariah L. McLean +43 · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Genetic Neurodegenerative Diseases #Mitochondrial Function and Pathology #Muscle Physiology and Disorders

paper · doi:10.1038/s41588-025-02191-5

openalex publication_date 2025/06/01 · openalex created_date 2025/06/10 · openalex updated_date 2026/07/23

Citations

• New insights into the genetic etiology of Alzheimer’s disease and related dementias
• Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease

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• Insights into DNA repeat expansions among 900,000 biobank participants