Stephan Ripke
- Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores
2015/10/01 by Bjarni J. Vilhjálmsson, Bjarni J. Vilhjálmsson, Jian Yang +452 · 61 citations
Biochemistry, Genetics and Molecular Biology · Mathematics · Medicine · #Advanced Causal Inference Techniques #Allele #Artificial intelligence #Bioinformatics and Genomic Networks #Biology #Computer science #Disequilibrium #Genetic Associations and Epidemiology #Genetics #Haplotype #Linkage disequilibrium #Mathematics #Medicine #Pattern recognition (psychology) #Polygenic risk score #Pruning #Sample (material) #Sample size determination #Single-nucleotide polymorphism #Statistics #Thresholding
- Biological insights from 108 schizophrenia-associated genetic loci
2014/07/01 by Stephan Ripke, B M Neale, Kai-How Farh +97 · 18 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Diabetes and associated disorders #Genetic Associations and Epidemiology #Tryptophan and brain disorders
- Estimation of SNP Heritability from Dense Genotype Data
2013/12/01 by S. Hong Lee, Sang Lee, Jian Yang +16 · 28 citations
Biochemistry, Genetics and Molecular Biology · #Biology #Cancer-related molecular mechanisms research #Gene #Genetic Mapping and Diversity in Plants and Animals #Genetic and phenotypic traits in livestock #Genetic architecture #Genetics #Genome-wide association study #Genotype #Heritability #Hum #MEDLINE #Quantitative trait locus #SNP #Scopus #Single-nucleotide polymorphism
- Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
2012/02/19 by S Hong Lee, Sang Lee, Teresa R DeCandia +12 · 8 citations
Biochemistry, Genetics and Molecular Biology · Psychology · #Biology #Computational biology #Evolutionary biology #Gene #Genetic Associations and Epidemiology #Genetic Mapping and Diversity in Plants and Animals #Genetic variation #Genetics #Genomic variations and chromosomal abnormalities #Genotype #Psychiatry #Psychology #Schizophrenia (object-oriented programming) #Single-nucleotide polymorphism #Variation (astronomy)
- Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders
2019/12/01 by Phil H. Lee, Verneri Anttila, Hyejung Won +628 · 1 voice · 8 citations
Biochemistry, Genetics and Molecular Biology · Psychology · #Genetic Associations and Epidemiology #Genomics and Rare Diseases #Obsessive-Compulsive Spectrum Disorders
- Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
2019/02/04 by David M. Howard, Mark J. Adams, Toni‐Kim Clarke +35 · 3 citations
Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Bioinformatics and Genomic Networks #Genetics and Neurodevelopmental Disorders
- Association of Granulomatosis With Polyangiitis (Wegener's) With HLA–DPB1*04 and SEMA6A Gene Variants: Evidence From Genome‐Wide Analysis
2013/06/05 by Gang Xie, Delnaz Roshandel, Richard Sherva +31 · 26 citations
Immunology and Microbiology · Medicine · #Allele #Antigen #Biology #Cohort #Gene #Genetic association #Genetics #Genome-wide association study #Genotype #Human leukocyte antigen #Inflammation biomarkers and pathways #Internal medicine #Medicine #Rheumatoid Arthritis Research and Therapies #SNP #Single-nucleotide polymorphism #Vasculitis and related conditions
- Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
2018/04/26 by eQTLGen, Naomi R. Wray, 23andMe +237 · 4 citations
Biochemistry, Genetics and Molecular Biology · #BRCA gene mutations in cancer #Genetic Associations and Epidemiology #Genetics and Neurodevelopmental Disorders
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
2024/07/05 by Nora I. Strom, Brad Verhulst, Silviu‐Alin Bacanu +97 · 1 voice · 3 citations
Biochemistry, Genetics and Molecular Biology · #Genetic Associations and Epidemiology #Genetics and Neurodevelopmental Disorders #Epigenetics and DNA Methylation
- Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
2013/08/11 by S Hong Lee, Bryan Mowry, E Byrne +97 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Biology #Computational biology #Gene #Genetic Associations and Epidemiology #Genetics #Genetics and Neurodevelopmental Disorders #Genome #Genome-wide association study #Genomics and Rare Diseases #Genotype #Single-nucleotide polymorphism
- Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling
2026/02/01 by Nora I. Strom, Brad Verhulst, Silviu-Alin Bacanu +97 · 1 voice · 6 citations
Biochemistry, Genetics and Molecular Biology · Psychology · #Allele #Anxiety #Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes #Association (psychology) #Genetic Associations and Epidemiology #Genetic architecture #Genetic association #Genetic variants #Genome-wide association study #Mechanism (biology) #Mental Health Research Topics #Neuroticism #Panic disorder
- Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health
2025/10/03 by Philippe Jawinski, Helena Forstbach, Holger Kirsten +6 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Mitochondrial Function and Pathology #Alzheimer's disease research and treatments #Genetic Associations and Epidemiology
- Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium
2017/09/22 by Wouter J. Peyrot, Sandra Van der Auwera, Pamela A. F. Madden +92 · 1 citation
Biochemistry, Genetics and Molecular Biology · Psychology · #Genetic Associations and Epidemiology #Cognitive Abilities and Testing #Child Abuse and Trauma