- 5α-Androstane-3α,17β-Diol Is Formed in Tammar Wallaby Pouch Young Testes by a Pathway Involving 5α-Pregnane-3α,17α-Diol-20-One as a Key Intermediate
2003/01/21 by Jean D. Wilson, Richard J. Auchus, Michael W. Leihy +5 · 3 citations
Medicine · Biochemistry, Genetics and Molecular Biology · Chemistry · #Hormonal and reproductive studies #Estrogen and related hormone effects #Sexual Differentiation and Disorders #Androsterone #Tammar wallaby #Pregnane #Androstane #Endocrinology #Internal medicine #Testosterone (patch) #Steroid #Dihydrotestosterone #Biology #Androgen #Chemistry #Biochemistry #Hormone #Medicine
- The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism
2002/10/01 by Steven A. Kliewer, Bryan Goodwin, Timothy M. Willson · 1 citation
Pharmacology, Toxicology and Pharmaceutics · Biochemistry, Genetics and Molecular Biology · Medicine · Chemistry · #Pharmacogenetics and Drug Metabolism #Estrogen and related hormone effects #Drug Transport and Resistance Mechanisms #Pregnane X receptor #Nuclear receptor #Xenobiotic #Constitutive androstane receptor #CYP3A4 #Drug metabolism #Pregnane #Chemistry #Biochemistry #Receptor #Ligand (biochemistry) #Pharmacology #Cytochrome P450 #Regulator #Biology #Metabolism #Gene #Transcription factor #Stereochemistry #Enzyme
- St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
2000/06/13 by Linda B. Moore, Bryan Goodwin, Stacey A. Jones +6 · 37 citations
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Angelica sinensis #Biochemistry #CYP3A4 #Chemistry #Cytochrome P450 #Drug #Drug Transport and Resistance Mechanisms #Drug metabolism #Human immunodeficiency virus (HIV) #Hyperforin #Hypericin #Hypericum #Hypericum perforatum #Indinavir #Medicine #Metabolism #Nuclear receptor #Pharmacogenetics and Drug Metabolism #Pharmacological Effects and Toxicity Studies #Pharmacology #Pregnane #Pregnane X receptor #Stereochemistry #Traditional medicine #Transcription factor
- The neuroactive steroid allopregnanolone suppresses hypothalamic gonadotropin-releasing hormone release through a mechanism mediated by the gamma-aminobutyric acidA receptor
1998/07/01 by AE Calogero, Aldo E. Calogero, MA Palumbo +13 · 15 citations
Chemistry · Medicine · Neuroscience · Psychology · #Agonist #Allopregnanolone #Bicuculline #Biology #Chemistry #Endocrinology #GABAA receptor #Hypothalamic control of reproductive hormones #Internal medicine #Medicine #Neuroactive steroid #Neuroendocrine regulation and behavior #Pregnane #Pregnanolone #Pregnenolone sulfate #Receptor #Stress Responses and Cortisol