Timothy M. Willson
- St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
2000/06/13 by Linda B. Moore, Bryan Goodwin, Stacey A. Jones +6 · 37 citations
Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Angelica sinensis #Biochemistry #CYP3A4 #Chemistry #Cytochrome P450 #Drug #Drug Transport and Resistance Mechanisms #Drug metabolism #Human immunodeficiency virus (HIV) #Hyperforin #Hypericin #Hypericum #Hypericum perforatum #Indinavir #Medicine #Metabolism #Nuclear receptor #Pharmacogenetics and Drug Metabolism #Pharmacological Effects and Toxicity Studies #Pharmacology #Pregnane #Pregnane X receptor #Stereochemistry #Traditional medicine #Transcription factor
- Cloning and Characterization of Human Estrogen Receptor β Isoforms
1998/06/01 by John T. Moore, David D. McKee, Kimberly Slentz-Kesler +10 · 9 citations
Biochemistry, Genetics and Molecular Biology · #Estrogen and related hormone effects #Genomics and Chromatin Dynamics #Insect Resistance and Genetics
- Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation
2018/03/20 by Marie Pariollaud, Julie E. Gibbs, Julie Gibbs +30 · 28 citations
Medicine · Neuroscience · #Asthma and respiratory diseases #Biology #Cell biology #Chemokine #Circadian clock #Circadian rhythm #Circadian rhythm and melatonin #Dietary Effects on Health #Immune system #Immunology #Inflammation #Innate immune system #Neuroscience #Proinflammatory cytokine
- Too many roads not taken
2011/02/08 by Ruth Isserlin, A.M. Edwards, Gary D. Bader +6 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Cancer Genomics and Diagnostics #Genomics and Rare Diseases #Ubiquitin and proteasome pathways #q-bio.GN #q-bio.OT
- ApoE Promotes the Proteolytic Degradation of Aβ
2008/06/01 by Qingguang Jiang, C.Y. Daniel Lee, Shweta Mandrekar +18 · 2 citations
Chemistry · Medicine · Neuroscience · #Agonist #Alzheimer's disease research and treatments #Apolipoprotein E #Autophagy #Biochemistry #Biology #Cell biology #Chemistry #Cholesterol and Lipid Metabolism #Disease #Drug Transport and Resistance Mechanisms #Endocrinology #Enzyme #Inflammation #Insulin-degrading enzyme #Internal medicine #Lipid-anchored protein #Medicine #Microglia #Neprilysin #Neuroinflammation #Neuroscience #Receptor
- The Nuclear Pregnane X Receptor: A Key Regulator of Xenobiotic Metabolism
2002/10/01 by Steven A. Kliewer, Bryan Goodwin, Timothy M. Willson · 1 citation
Pharmacology, Toxicology and Pharmaceutics · Biochemistry, Genetics and Molecular Biology · Medicine · Chemistry · #Pharmacogenetics and Drug Metabolism #Estrogen and related hormone effects #Drug Transport and Resistance Mechanisms #Pregnane X receptor #Nuclear receptor #Xenobiotic #Constitutive androstane receptor #CYP3A4 #Drug metabolism #Pregnane #Chemistry #Biochemistry #Receptor #Ligand (biochemistry) #Pharmacology #Cytochrome P450 #Regulator #Biology #Metabolism #Gene #Transcription factor #Stereochemistry #Enzyme
- The enabling power of chemical probes: examples from the nuclear hormone receptor field
2026/07/23 by Timothy M. Willson, Timothy M. Willson, Daniel Merk
Biochemistry, Genetics and Molecular Biology · Medicine · #Peroxisome Proliferator-Activated Receptors #Estrogen and related hormone effects #Cholesterol and Lipid Metabolism