Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003/02/13 by Shohei Hori, Takashi Nomura, Shimon Sakaguchi · 14 citations
Immunology and Microbiology · Medicine · #Immune Cell Function and Interaction #T-cell and B-cell Immunology #CAR-T cell therapy research

paper · doi:10.1126/science.1079490

openalex publication_date 2003/02/13 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/04

Abstract

Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+ regulatory T cells. Thus, Foxp3 is a key regulatory gene for the development of regulatory T cells.

Citations

• The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
• X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
• Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
• Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

Cited by

• Foxp3 occupancy and regulation of key target genes during T-cell stimulation
• FOXP3 ensembles in T‐cell regulation
• Mutational Analysis of the FOXP3 Gene and Evidence for Genetic Heterogeneity in the Immunodysregulation, Polyendocrinopathy, Enteropathy Syndrome
• Regulatory T cells in experimental autoimmune disease
• Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
• FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
• The regulation of Foxp3 expression in regulatory CD4+CD25+T cells: Multiple pathways on the road
• FOXP3: Not just for regulatory T cells anymore
• The role of the FOXP3 transcription factor in the immune regulation of allergic asthma
• A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes
• Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies
• The speed of change: towards a discontinuity theory of immunity?
• The Human T Cell Response to Melanoma Antigens
• FOXP3 [wikipedia]