FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

2006/07/01 by Yongqing Wu, Madhuri Borde, Vigo Heissmeyer +13 · 4 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Immune Cell Function and Interaction #Signaling Pathways in Disease #T-cell and B-cell Immunology

paper · pdf · doi:10.1016/j.cell.2006.05.042

crossref issued 2006/07/01 · crossref published 2006/07/01 · crossref published-print 2006/07/01 · openalex publication_date 2006/07/01 · crossref created 2006/08/01 · crossref deposited 2025/09/25 · openalex created_date 2025/10/10 · crossref indexed 2026/07/09 · openalex updated_date 2026/08/01

Citations

• The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
• X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
• Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
• Control of Regulatory T Cell Development by the Transcription Factor Foxp3
• Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation
• Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Cited by

• The regulation of Foxp3 expression in regulatory CD4+CD25+T cells: Multiple pathways on the road
• FOXP3: Not just for regulatory T cells anymore
• Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies
• FOXP3 [wikipedia]