FOXP3 ensembles in T‐cell regulation

2006/07/21 by Bin Li, Arabinda Samanta, Xiaomin Song +6 · 1 citation
Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #Immune Cell Function and Interaction #T-cell and B-cell Immunology #Cancer-related molecular mechanisms research

paper · doi:10.1111/j.0105-2896.2006.00405.x

openalex publication_date 2006/07/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/15

Abstract

Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T-cell activities, and it is our goal to determine how these ensembles regulate FOXP3's transcriptional activity in vivo. In this review, we summarize our current understanding of how FOXP3 expression is induced and how FOXP3 functions in vivo as a transcriptional regulator by assembling a multisubunit complex involved in histone modification as well as chromatin remodeling.

Citations

• The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
• X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
• Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
• Control of Regulatory T Cell Development by the Transcription Factor Foxp3
• The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
• Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells
• Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue
• Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
• Mechanisms of Alternative Pre-Messenger RNA Splicing

Cited by

• FOXP3 [wikipedia]