Mechanisms of Alternative Pre-Messenger RNA Splicing

2003/03/04 by Douglas L. Black · 8 citations
Biochemistry, Genetics and Molecular Biology · #RNA Research and Splicing #RNA modifications and cancer #RNA and protein synthesis mechanisms

paper · doi:10.1146/annurev.biochem.72.121801.161720

openalex publication_date 2003/03/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Alternative pre-mRNA splicing is a central mode of genetic regulation in higher eukaryotes. Variability in splicing patterns is a major source of protein diversity from the genome. In this review, I describe what is currently known of the molecular mechanisms that control changes in splice site choice. I start with the best-characterized systems from the Drosophila sex determination pathway, and then describe the regulators of other systems about whose mechanisms there is some data. How these regulators are combined into complex systems of tissue-specific splicing is discussed. In conclusion, very recent studies are presented that point to new directions for understanding alternative splicing and its mechanisms.

Citations

• Identification of Novel Genes Coding for Small Expressed RNAs
• An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

Cited by

• FOXP3 ensembles in T‐cell regulation
• One Hundred Years of Pleiotropy: A Retrospective
• A single-nucleotide exon found in Arabidopsis
• Expression Changes Confirm Genomic Variants Predicted to Result in Allele-Specific, Alternative mRNA Splicing
• Noisy Splicing Drives mRNA Isoform Diversity in Human Cells
• Spliceosomes walk the line: Splicing errors and their impact on cellular function
• Genomic variants in exons and introns: identifying the splicing spoilers
• Cell nucleus [wikipedia]