Multiple Metal–Carbon Bonds for Catalytic Metathesis Reactions (Nobel Lecture)

2006/05/16 by Richard R. Schrock · 4 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Chemical Synthesis and Analysis #Organometallic Complex Synthesis and Catalysis #Synthetic Organic Chemistry Methods

paper · doi:10.1002/anie.200600085

openalex publication_date 2006/05/16 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Abstract

Metathesis reactions are among the most important processes in organic synthesis. The decisive breakthrough in making these reactions practical for industrial purposes, which range from the synthesis of polymers to pharmaceuticals, came with the discovery of the reaction mechanism by Yves Chauvin and the targeted development of transition-metal-based metathesis catalysts by Richard Schrock and Robert Grubbs. The winners of the Chemistry Nobel Prize in 2005 present first-hand accounts of these developments.

Citations

• Catalyse de transformation des oléfines par les complexes du tungstène. II. Télomérisation des oléfines cycliques en présence d'oléfines acycliques
• Enantioselective Synthesis of Medium-Ring Heterocycles, Tertiary Ethers, and Tertiary Alcohols by Mo−Catalyzed Ring-Closing Metathesis
• The application of catalytic ring-closing olefin metathesis to the synthesis of unsaturated oxygen heterocycles
• The synthesis of nitrogen heterocycles via catalytic ring-closing metathesis of dienes

Cited by

• Equilibrium Ring-Closing Metathesis
• Highly Efficient Ruthenium Catalysts for the Formation of Tetrasubstituted Olefins via Ring-Closing Metathesis
• Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
• Ring-closing metathesis [wikipedia]