Enantioselective Synthesis of Medium-Ring Heterocycles, Tertiary Ethers, and Tertiary Alcohols by Mo−Catalyzed Ring-Closing Metathesis

2002/03/01 by Andrew F. Kiely, Jesper A. Jernelius, Richard R. Schrock +1 · 3 citations
Chemistry · Biochemistry, Genetics and Molecular Biology · #Synthetic Organic Chemistry Methods #Chemical Synthesis and Analysis #Organometallic Complex Synthesis and Catalysis

paper · doi:10.1021/ja012679s

openalex publication_date 2002/03/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

The Mo-catalyzed asymmetric ring-closing metathesis (ARCM) of various achiral trienes leads to the formation of medium-ring unsaturated heterocycles in high yield and with excellent enantioselectivity. Reactions may be carried out on gram scale and in the absence of solvent. The unsaturated siloxanes obtained enantioselectively can be readily functionalized to obtain synthetically useful and difficult-to-access tertiary alcohols.

Cited by

• Enantioselective Synthesis of P‐Stereogenic Phosphinates and Phosphine Oxides by Molybdenum‐Catalyzed Asymmetric Ring‐Closing Metathesis
• Multiple Metal–Carbon Bonds for Catalytic Metathesis Reactions (Nobel Lecture)
• Ring-closing metathesis [wikipedia]