Enantioselective Synthesis of P‐Stereogenic Phosphinates and Phosphine Oxides by Molybdenum‐Catalyzed Asymmetric Ring‐Closing Metathesis

2008/12/25 by James Harvey, Steven J. Malcolmson, Katherine S. Dunne +5 · 1 citation
Chemistry · Biochemistry, Genetics and Molecular Biology · #Synthetic Organic Chemistry Methods #Chemical Synthesis and Analysis #Asymmetric Hydrogenation and Catalysis

paper · doi:10.1002/anie.200805066

openalex publication_date 2008/12/25 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/16

Abstract

The first catalytic route toward the title compounds by asymmetric ring-closing metathesis is described. A remarkable reversal of enantioselectivity is observed when the achiral imido ligand of the chiral molybdenum-catalyst is changed (see scheme), thus highlighting the importance of the achiral and the chiral ligands in catalyst design.

Citations

• Enantioselective Synthesis of Medium-Ring Heterocycles, Tertiary Ethers, and Tertiary Alcohols by Mo−Catalyzed Ring-Closing Metathesis

Cited by

• Ring-closing metathesis [wikipedia]

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