A crystalline chiral phosphide for the synthesis of the first P-stereogenic P( <scp>iii</scp> ) fluoride: a stable ligand for the Rh-catalyzed asymmetric arylation of isatins

2025/12/18 by Laila Al Baridi, Giorgio Parla, Alberto Herrera +2 · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Catalytic Cross-Coupling Reactions #Fluorine in Organic Chemistry #Organoboron and organosilicon chemistry

paper · pdf · doi:10.1039/d5qi01994j

openalex created_date 2025/12/18 · openalex publication_date 2025/12/18 · openalex updated_date 2026/07/28

Abstract

Electrophilic fluorination of a crystalline phosphide yields the first stable P-stereogenic P( iii ) fluoride, which is an excellent ligand for asymmetric catalysis.

Discussions

• Research article by Romano Dorta's team. #FAU Authors report a crystalline chiral lithium alkene-phosphide that undergoes rapid, enantiospecific fluorination to give a fluorophosphinamide–alkene lig [bsky, 1 points, 0 comments]

Related

• A Planar-Chiral Pillar[5]arene-Based Monophosphine Ligand with Induced Chirality at the Biaryl Axis
• Flash Communication: An <i>ortho</i>-Trifluoromethylphenyl Substituted Phosphine Ligand for Applications in Gold(I) Catalysis
• Ligand-Enabled Cu-Catalyzed Stereoselective Synthesis of P-Stereogenic ProTides
• Catalytic construction of P-stereogenic center via phosphorus-centered nucleophilic substitution
• Chiral Phosphoric Acids as Versatile Catalysts for Enantioselective Transformations