1992/06/01 by Gregory C. Fu, Robert H. Grubbs · 4 citations
Chemistry · Engineering · #Synthetic Organic Chemistry Methods #Fuel Cells and Related Materials #Asymmetric Hydrogenation and Catalysis
paper · doi:10.1021/ja00039a065
openalex publication_date 1992/06/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/11
The development of general approaches to carbon-carbon bond formation represents an important ongoing challenge for synthetic organic chemists. One efficient method for constructing carbon-carbon double bonds, the transition metal alkylidene-catalyzed olefin metathesis reaction (eq 1), has been the focus of intense interest in recent years from the standpoint of both mechanism and polymer synthesis; in contrast, use of this transformation in organic synthesis has been limited. As part of a broader program directed toward establishing transition metal alkylidenes as versatile reagents for organic chemistry, we report the successful application of catalytic olefin metathesis to the generation of a variety of unsaturated oxygen heterocycles.