Palladium-catalysed regio- and stereo-controlled C-2 β-fluorovinylation of indoles

2025/01/01 by Atul Chaturvedi, Alastair J. J. Lennox · 1 voice
Pharmacology, Toxicology and Pharmaceutics · #Fluorine in Organic Chemistry

paper · pdf · doi:10.1039/d5qo00521c

openalex publication_date 2025/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/26

Abstract

-Fluorovinyl iodonium salts, which are formed from alkynes through a Ag-catalysed process, engage in a palladium-catalysed C-2 C-H functionalisation of indoles (and pyrroles) to achieve a broad scope of β-fluorovinyl heterocycles in good to excellent yields. Mechanistic studies and product derivatisations are provided.

Citations

• Contribution of Organofluorine Compounds to Pharmaceuticals
• Fluorinated Pyrazoles: From Synthesis to Applications
• An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023)

Discussions

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