Capturing CO: palladium-catalyzed, BrCF 2 COOK-mediated one-pot carbonylative coupling for the synthesis of oxindoles

2026/01/01 by Shivam A. Meena, Deepika Thakur, Manvi Sharma +1 · 1 voice
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Catalytic Cross-Coupling Reactions #Catalytic C–H Functionalization Methods #Fluorine in Organic Chemistry

paper · doi:10.1039/d6qo00177g

openalex publication_date 2026/01/01 · openalex created_date 2026/04/10 · openalex updated_date 2026/06/26

Abstract

We herein report a Pd-catalyzed difluorocarbene transfer reaction that enables the efficient synthesis of carbonylative oxindole derivatives in good to excellent yields. In this transformation, commercially available BrCF 2 COOK functions as practical difluorocarbene precursor and a safe, user-friendly carbonyl source.

Citations

• Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides
• Recent progress on selective deconstructive modes of halodifluoromethyl and trifluoromethyl-containing reagents

Discussions

• 🔔 Research article by Akhilesh K. Verma 𝘦𝘵 𝘢𝘭. Capturing CO: palladium-catalyzed, BrCF₂COOK-mediated one-pot carbonylative coupling for the synthesis of oxindoles 🔗 doi.org/10.1039/D6QO... #R [bsky, 0 points, 0 comments]

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