2008/09/01 by CARMEN DRAHL · 1 citation
Medicine · Arts and Humanities · #History of Medical Practice #Twentieth Century Scientific Developments
paper · doi:10.1021/cen-v086n035.p053
openalex publication_date 2008/09/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
PALLADIUM CATALYSTS are widely used for making carbon-carbon, carbon-nitrogen, and carbon-oxygen bonds for agrochemicals, pharmaceuticals, and materials. But new research is revealing that chemists can do a lot more than that with Pd. New structural evidence indicates that Pd can build carbon-fluorine bonds by a versatile mechanism that could open the way to many new synthetic pathways valuable to materials scientists, medicinal chemists, and others. In the key mechanistic finding, chemist Tobias Ritter and graduate student Takeru Furuya of Harvard University observed an elusive intermediate in a Pd-mediated C–F bond-forming reaction ( J. Am. Chem. Soc. 2008, 130, 10060). The intermediate breaks down to yield fluorinated products by a pathway called reductive elimination. Reductive elimination is the last step in Pd-mediated reactions that form many other bonds. Although chemists have suspected involvement of this important intermediate in this type of fluorination, until now no one has conclusively demonstrated its presence. The pharmaceutical industry uses reductive elimination ...