2020/12/31 by Pavel K. Mykhailiuk · 2 citations
Chemistry · Pharmacology, Toxicology and Pharmaceutics · #Fluorine in Organic Chemistry #Synthesis and Biological Evaluation #Synthesis and Reactions of Organic Compounds
paper · doi:10.1021/acs.chemrev.0c01015
openalex publication_date 2020/12/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/21
Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s, their popularity has grown exponentially. Moreover, more than 50% of all contributions on the topic have been published in the last 5 years. In this review, analysis of novel synthetic approaches to fluorinated pyrazoles that appeared in recent years is performed. A particular emphasis is devoted to a detailed consideration of reaction mechanisms. In addition, the reasons that have led to the ever-increasing popularity of fluorinated pyrazoles in various areas of science are discussed. At the end of the review, several potentially interesting but yet mostly unknown classes of fluorinated pyrazoles are outlined.