ColabFold: making protein folding accessible to all
2022/05/30 by Milot Mirdita, Konstantin Schütze, Yoshitaka Moriwaki +3 · 269 citations
Biochemistry, Genetics and Molecular Biology · #Genomics and Phylogenetic Studies #Machine Learning in Bioinformatics #Protein Structure and Dynamics
paper · pdf · doi:10.1038/s41592-022-01488-1
openalex publication_date 2022/05/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Abstract
ColabFold offers accelerated prediction of protein structures and complexes by combining the fast homology search of MMseqs2 with AlphaFold2 or RoseTTAFold. ColabFold's 40-60-fold faster search and optimized model utilization enables prediction of close to 1,000 structures per day on a server with one graphics processing unit. Coupled with Google Colaboratory, ColabFold becomes a free and accessible platform for protein folding. ColabFold is open-source software available at https://github.com/sokrypton/ColabFold and its novel environmental databases are available at https://colabfold.mmseqs.com .
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