2026/02/11 by Sean D. Keeley, Rita Aires, Belfran Carbonell Medina +6 · 1 voice
Biochemistry, Genetics and Molecular Biology · #Developmental Biology and Gene Regulation #dental development and anomalies #Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
paper · doi:10.1016/j.isci.2026.114934
openalex publication_date 2026/02/11 · openalex created_date 2026/02/11 · openalex updated_date 2026/07/23
and revealed an undescribed four-member Kazald gene family in jawed vertebrates. Synteny comparisons demonstrated that this family originated in the two-round whole-genome duplication event. Additionally, vertebrate-wide comparisons of Kazald expression, validated in tissues of axolotl, zebrafish, and sharks, uncovered seemingly ancestral connections conserved over jawed vertebrate evolution, and suggested novel putative roles within specific lineages. Our study demonstrates the establishment of the Kazald family in the jawed vertebrate ancestor and elucidates the asymmetry of gene fates of its members. This provides a comprehensive report of this formerly undescribed gene family, offering a solid foundation for its study in diverse species.