A general system for targeting MHC class II–antigen complex via a single adaptable loop

2024/12/13 by Haotian Du, Jingjia Liu, Kevin M. Jude +17 · 1 voice · 1 citation
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Immunotherapy and Immune Responses #Monoclonal and Polyclonal Antibodies Research #vaccines and immunoinformatics approaches

paper · doi:10.1038/s41587-024-02466-y

crossref issued 2024/12/13 · crossref published 2024/12/13 · crossref published-online 2024/12/13 · openalex publication_date 2024/12/13 · crossref created 2024/12/13 · crossref published-print 2025/10/01 · openalex created_date 2025/10/10 · crossref deposited 2025/10/15 · crossref indexed 2026/07/17 · openalex updated_date 2026/07/28

Citations

• UCSF ChimeraX: Structure visualization for researchers, educators, and developers
• DeepEMhancer: a deep learning solution for cryo-EM volume post-processing
• A guide to antigen processing and presentation
• ColabFold: making protein folding accessible to all
• De novo design of protein structure and function with RFdiffusion

Cited by

• Generating allogeneic CAR-NKT cells for off-the-shelf cancer immunotherapy with genetically engineered HSP cells and feeder-free differentiation culture

Discussions

• 🖐️ Hi Mam! - A superantigen (MAM) goes to the head of the class (II) to find alternatives to TCRs for specific peptide:MHC binders doi.org/10.1038/s415... [bsky, 3 points, 0 comments]