Robert J. Lefkowitz

1. Seven-transmembrane receptors
   2002/09/01 by Kristen L. Pierce, Richard T. Premont, Robert J. Lefkowitz · 7 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Cholesterol and Lipid Metabolism #Neuropeptides and Animal Physiology #Receptor Mechanisms and Signaling
2. The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
   2002/02/01 by Louis M. Luttrell, Robert J. Lefkowitz · 5 citations
   Biochemistry, Genetics and Molecular Biology · Neuroscience · #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology #Protein Kinase Regulation and GTPase Signaling
3. Cloning of the cDNA for the human beta 1-adrenergic receptor.
   1987/11/01 by Thomas Frielle, Sheila Collins, Kiefer W. Daniel +3 · 4 citations
   Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · Medicine · #Receptor Mechanisms and Signaling #Pharmacological Effects and Assays #Adipose Tissue and Metabolism
4. Regulation of β2-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies
   2013/12/07 by Dean P. Staus, Laura M. Wingler, Ryan T. Strachan +7 · 27 citations
   Biochemistry, Genetics and Molecular Biology · Neuroscience · Medicine · #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology #Monoclonal and Polyclonal Antibodies Research
5. β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
   1990/06/22 by Martin J. Lohse, Jeffrey Benovic, Juan Codina +2 · 3 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Receptor Mechanisms and Signaling #Renin-Angiotensin System Studies #Pharmacogenetics and Drug Metabolism
6. The Role of Sequestration in G Protein-coupled Receptor Resensitization
   1997/01/01 by Kathleen M. Krueger, Yehia Daaka, Julie A. Pitcher +1 · 4 citations
   Biochemistry, Genetics and Molecular Biology · Neuroscience · Medicine · #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology #Diabetes Treatment and Management
7. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
   2016/08/01 by Alex R.B. Thomsen, A. Thomsen, Bianca Plouffe +18 · 3 citations
   Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Neuropeptides and Animal Physiology #Pancreatic function and diabetes #Receptor Mechanisms and Signaling
8. Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the β1-adrenergic receptor
   1999/10/26 by Yuting Tang, Liaoyuan A. Hu, William E. Miller +5 · 2 citations
   Biochemistry, Genetics and Molecular Biology · Neuroscience · #Receptor Mechanisms and Signaling #Nicotinic Acetylcholine Receptors Study #Neuropeptides and Animal Physiology
9. β1-Adrenergic Receptor Association with PSD-95
   2000/12/01 by Liaoyuan A. Hu, Yuting Tang, William E. Miller +4 · 2 citations
   Biochemistry, Genetics and Molecular Biology · Neuroscience · Medicine · #Receptor Mechanisms and Signaling #Neuroscience and Neuropharmacology Research #Cancer, Stress, Anesthesia, and Immune Response
10. Human β1- and β2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes
    1988/01/01 by Thomas Frielle, Brian Kobilka, Brian K. Kobilka +2 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Neuroscience · #Neuroscience and Neuropharmacology Research #Photoreceptor and optogenetics research #Receptor Mechanisms and Signaling
11. The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling.
    1983/07/01 by Gary L. Stiles, R. H. Strasser, T N Lavin +3 · 1 citation
    Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Neuroscience · #Pharmacological Effects and Assays #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology
12. G Protein-coupled Receptor Kinase 5 Regulates β1-Adrenergic Receptor Association with PSD-95
    2002/01/01 by Liaoyuan A. Hu, Wei Chen, Richard T. Premont +2 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Neuroscience · #Agonist #Beta adrenergic receptor kinase #Biochemistry #Biology #Cell biology #G protein-coupled receptor #G protein-coupled receptor kinase #Gene #Immunoprecipitation #Kinase #Mutant #Neuropeptides and Animal Physiology #Neuroscience and Neuropharmacology Research #PDZ domain #Phosphorylation #Protein kinase domain #Receptor #Receptor Mechanisms and Signaling #Signal transduction
13. Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis
    2017/02/21 by Thomas J. Cahill, A. Thomsen, Jeffrey Tarrasch +24 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Neuroscience · #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology #Protein Kinase Regulation and GTPase Signaling
14. Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex
    2019/11/18 by Anthony H. Nguyen, A. Thomsen, Alex R. B. Thomsen +26 · 1 citation
    Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Mass Spectrometry Techniques and Applications #Neuropeptides and Animal Physiology #Receptor Mechanisms and Signaling