Brian K. Kobilka
- Functional Selectivity and Classical Concepts of Quantitative Pharmacology
2006/06/28 by Jonathan D. Urban, William P. Clarke, Mark von Zastrow +11 · 45 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Pharmacology, Toxicology and Pharmaceutics · #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology #Pharmacogenetics and Drug Metabolism
- High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007/10/25 by Vadim Cherezov, Daniel M. Rosenbaum, Michael A. Hanson +8 · 14 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Computer Science · #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology #Computational Drug Discovery Methods
- The Molecular Basis of G Protein–Coupled Receptor Activation
2018/06/20 by William I. Weis, Brian K. Kobilka · 14 citations
Biochemistry, Genetics and Molecular Biology · Computer Science · Neuroscience · #Receptor Mechanisms and Signaling #Computational Drug Discovery Methods #Neuropeptides and Animal Physiology
- Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007/10/21 by Søren G. F. Rasmussen, Hee-Jung Choi, Hee‐Jung Choi +11 · 10 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Neuroscience and Neuropharmacology Research #Photoreceptor and optogenetics research #Receptor Mechanisms and Signaling
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011/07/19 by Søren G. F. Rasmussen, Brian T. DeVree, Yaozhong Zou +19 · 6 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Neuroscience · #Mass Spectrometry Techniques and Applications #Neuroscience and Neuropharmacology Research #Receptor Mechanisms and Signaling
- Cloning of the cDNA for the human beta 1-adrenergic receptor.
1987/11/01 by Thomas Frielle, Sheila Collins, Kiefer W. Daniel +3 · 4 citations
Biochemistry, Genetics and Molecular Biology · Agricultural and Biological Sciences · Medicine · #Receptor Mechanisms and Signaling #Pharmacological Effects and Assays #Adipose Tissue and Metabolism
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011/01/01 by Søren G. F. Rasmussen, Hee-Jung Choi, Hee‐Jung Choi +17 · 7 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Lipid Membrane Structure and Behavior #Photoreceptor and optogenetics research #Receptor Mechanisms and Signaling
- Regulation of β2-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies
2013/12/07 by Dean P. Staus, Laura M. Wingler, Ryan T. Strachan +7 · 27 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Medicine · #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology #Monoclonal and Polyclonal Antibodies Research
- GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007/10/25 by Daniel M. Rosenbaum, Vadim Cherezov, Michael A. Hanson +8 · 7 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Agricultural and Biological Sciences · #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology #Pharmacological Effects and Assays
- The structure and function of G-protein-coupled receptors
2009/05/01 by Daniel M. Rosenbaum, Søren G. F. Rasmussen, Brian K. Kobilka · 2 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Lipid Membrane Structure and Behavior #Neuropeptides and Animal Physiology #Receptor Mechanisms and Signaling
- Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011/01/01 by Daniel M. Rosenbaum, Cheng Zhang, Joseph A. Lyons +17 · 4 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Neuropeptides and Animal Physiology #Neuroscience and Neuropharmacology Research #Receptor Mechanisms and Signaling
- Human β1- and β2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes
1988/01/01 by Thomas Frielle, Brian K. Kobilka, Brian Kobilka +2 · 1 citation
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Neuroscience and Neuropharmacology Research #Photoreceptor and optogenetics research #Receptor Mechanisms and Signaling