Johannes Kornhuber
- Flupirtine shows functional NMDA receptor antagonism by enhancing Mg 2+ block via activation of voltage independent potassium channels
1999/10/20 by Johannes Kornhuber, J. Kornhuber, S. Bleich +7 · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Ion channel regulation and function #Neuroscience and Neuropharmacology Research #Pain Mechanisms and Treatments
- Persistence of Haloperidol in Human Brain Tissue
1999/06/01 by Johannes Kornhuber, Andreas Schultz, Jens Wiltfang +6 · 3 citations
Medicine · Neuroscience · #Schizophrenia research and treatment #Neurotransmitter Receptor Influence on Behavior #Treatment of Major Depression
- Poly‐GP in cerebrospinal fluid links C9orf72‐associated dipeptide repeat expression to the asymptomatic phase of ALS/FTD
2017/04/13 by Carina Lehmer, Patrick Oeckl, Jochen H. Weishaupt +29 · 3 citations
Medicine · Neuroscience · #Amyotrophic Lateral Sclerosis Research #Genetic Neurodegenerative Diseases #Neurogenetic and Muscular Disorders Research
- Cerebrospinal fluid cortisol and clinical disease progression in MCI and dementia of Alzheimer's type
2014/10/31 by Julius Popp, Steffen Wolfsgruber, Isabella Heuser +16 · 1 citation
Neuroscience · Medicine · #Stress Responses and Cortisol #Tryptophan and brain disorders #Alzheimer's disease research and treatments
- Epigenetic DNA Hypermethylation of the HERP Gene Promoter Induces Down‐regulation of Its mRNA Expression in Patients With Alcohol Dependence
2006/03/29 by Stefan Bleich, Bernd Lenz, Marc Ziegenbein +4 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Alcohol Consumption and Health Effects #Epigenetics and DNA Methylation #Folate and B Vitamins Research
- Identification of New Functional Inhibitors of Acid Sphingomyelinase Using a Structure−Property−Activity Relation Model
2007/11/21 by Johannes Kornhuber, Philipp Tripal, Martin Reichel +4 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Sphingolipid Metabolism and Signaling #Lipid Membrane Structure and Behavior #Lysosomal Storage Disorders Research
- Region specific distribution of levomepromazine in the human brain
2005/07/04 by Johannes Kornhuber, J. Kornhuber, H. Weigmann +16 · 1 citation
Medicine · Neuroscience · #Epilepsy research and treatment #Neurotransmitter Receptor Influence on Behavior #Poisoning and overdose treatments
- Quantitative modeling of selective lysosomal targeting for drug design
2008/05/26 by Stefan Trapp, Gus R. Rosania, Richard W. Horobin +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Calcium signaling and nucleotide metabolism #Lysosomal Storage Disorders Research #Retinoids in leukemia and cellular processes
- Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression
2017/11/15 by Petra Steinacker, Federico Verde, Lubin Fang +27 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Amyotrophic Lateral Sclerosis Research #Amyotrophic lateral sclerosis #Central nervous system disease #Cerebrospinal fluid #Degenerative disease #Dementia #Differential diagnosis #Disease #Frontotemporal dementia #Frontotemporal lobar degeneration #Immunohistochemistry #Immunology #Inflammation #Internal medicine #Medicine #Microglia #Neurofilament #Pathology #Spinal Cord Injury Research #Spinal cord #Studies on Chitinases and Chitosanases
- Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls
2018/05/10 by Johannes Denk, Felix Oberhauser, Johannes Kornhuber +12 · 1 citation
Medicine · Neuroscience · #Alzheimer's disease research and treatments #Neuroinflammation and Neurodegeneration Mechanisms #Dementia and Cognitive Impairment Research
- Konsortium zur Erforschung der frontotemporalen Lobärdegeneration
2011/07/29 by M. Otto, Markus Otto, A.C. Ludolph +16 · 1 citation
Medicine · Neuroscience · Psychology · #Alzheimer's disease research and treatments #Amyotrophic Lateral Sclerosis Research #Amyotrophic lateral sclerosis #Aphasia #Corticobasal degeneration #Dementia #Disease #Frontotemporal dementia #Frontotemporal lobar degeneration #Medicine #Neurological diseases and metabolism #Neuroscience #Pathology #Primary progressive aphasia #Progressive supranuclear palsy #Psychology #Semantic dementia
- Fluoxetine prevents stimulation‐dependent fatigue of synaptic vesicle exocytosis in hippocampal neurons
2010/05/06 by Andreas Henkel, Oliver Welzel, Teja W. Groemer +3 · 1 citation
Neuroscience · #Neuroscience and Neural Engineering #Neural dynamics and brain function #Photoreceptor and optogenetics research
- Identification of Novel Functional Inhibitors of Acid Sphingomyelinase
2011/08/31 by Johannes Kornhuber, Markus Muehlbacher, Stefan Trapp +10 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Sphingolipid Metabolism and Signaling #Drug Transport and Resistance Mechanisms #Lipid Membrane Structure and Behavior
- Positive reinforcing effects of flupirtine — Two case reports
2010/03/31 by Christina Stoessel, C. Stoessel, A. Heberlein +7 · 1 citation
Materials Science · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Peripheral Neuropathies and Disorders #Phytochemistry and Bioactive Compounds #Plant-based Medicinal Research