A Potent and Selective Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator Improves Movement in Rodent Models of Parkinson's Disease

2012/07/12 by Emmanuel Le Poul, Christelle Boléa, Françoise Girard +19 · 4 citations
Neuroscience · Materials Science · #Neuroscience and Neuropharmacology Research #Photochromic and Fluorescence Chemistry #Photoreceptor and optogenetics research

paper · doi:10.1124/jpet.112.196063

Citations

• The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson’s Disease

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• Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders
• Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist
• mGlu4 allosteric modulation for treating Parkinson's disease
• Effect of the mGlu4 positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset