The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson’s Disease

2011/11/17 by Carrie K. Jones, Michael Bubser, Analisa D. Thompson +16 · 4 citations
Neuroscience · Biochemistry, Genetics and Molecular Biology · #Neuroscience and Neuropharmacology Research #Neuroscience and Neural Engineering #Receptor Mechanisms and Signaling

paper · doi:10.1124/jpet.111.187443

Cited by

• A Potent and Selective Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator Improves Movement in Rodent Models of Parkinson's Disease
• Synergy between l-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia
• Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist
• mGlu4 allosteric modulation for treating Parkinson's disease