Synergy between l-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: Implications for Parkinson's disease treatment and dyskinesia

2012/04/04 by Khaled-Ezaheir Bennouar, Michelle A. Uberti, Christophe Melon +8 · 98 citations
Chemistry · Medicine · Neuroscience · Psychology · #Agonist #Allosteric modulator #Allosteric regulation #Chemistry #Dopamine #Dopaminergic #Glutamate receptor #Internal medicine #Medicine #Metabotropic glutamate receptor #Neurological disorders and treatments #Neuroscience #Neuroscience and Neural Engineering #Neuroscience and Neuropharmacology Research #Pars compacta #Pharmacology #Psychology #Receptor #Substantia nigra

paper · doi:10.1016/j.neuropharm.2012.03.022

published in Neuropharmacology 66, 158-169 (Elsevier BV)

openalex publication_date 2012/04/04 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Citations

• The Metabotropic Glutamate Receptor 4-Positive Allosteric Modulator VU0364770 Produces Efficacy Alone and in Combination with l-DOPA or an Adenosine 2A Antagonist in Preclinical Rodent Models of Parkinson’s Disease

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• Pharmacological Treatments Inhibiting Levodopa-Induced Dyskinesias in MPTP-Lesioned Monkeys: Brain Glutamate Biochemical Correlates. [europepmc]
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• Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist. [europepmc]
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• Current Nondopaminergic Therapeutic Options for Motor Symptoms of Parkinson's Disease. [europepmc]
• Discovery of VU2957 (Valiglurax): An mGlu 4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson's Disease. [europepmc]
• Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson's Disease. [europepmc]
• The Modulation of Pain by Metabotropic Glutamate Receptors 7 and 8 in the Dorsal Striatum. [europepmc]
• Roles of Glutamate Receptors in Parkinson's Disease. [europepmc]
• Family C G-Protein-Coupled Receptors in Alzheimer's Disease and Therapeutic Implications. [europepmc]
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• New 1,2,4-oxadiazole derivatives with positive mGlu 4 receptor modulation activity and antipsychotic-like properties. [europepmc]
• Allosteric Modulators of Metabotropic Glutamate Receptors as Novel Therapeutics for Neuropsychiatric Disease. [europepmc]
• Metabotropic Glutamate Receptor 4 (mGlu4) Positive Allosteric Modulators Lack Efficacy in Rat and Marmoset Models of L-DOPA-Induced Dyskinesia. [europepmc]
• Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer. [europepmc]