Effect of the mGlu4 positive allosteric modulator ADX-88178 on parkinsonism, psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset

2023/07/29 by Imane Frouni, Cynthia Kwan, Dominique Bédard +5
Medicine · Neuroscience · Biochemistry, Genetics and Molecular Biology · #Parkinson's Disease Mechanisms and Treatments #Neuroscience and Neuropharmacology Research #Phosphodiesterase function and regulation

paper · doi:10.1007/s00213-023-06428-1

Citations

• l-DOPA pharmacokinetics in the MPTP-lesioned macaque model of Parkinson's disease
• Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and l-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist
• Characterization of the Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 ADX88178 in Rodent Models of Neuropsychiatric Disorders
• A Potent and Selective Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator Improves Movement in Rodent Models of Parkinson's Disease
• mGlu4 allosteric modulation for treating Parkinson's disease
• Predictive Value of Parkinsonian Primates in Pharmacologic Studies: A Comparison between the Macaque, Marmoset, and Squirrel Monkey