Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

2006/07/01 by Sara Cipolat, Tomasz Rudka, Dieter Hartmann +16 · 622 citations
Biochemistry, Genetics and Molecular Biology · #ATP Synthase and ATPases Research #Apoptosis #Autophagy #Bacterial outer membrane #Biochemistry #Biology #Cell biology #Cell death mechanisms and regulation #Cytochrome c #Genetics #Intermembrane space #MFN2 #Mitochondrial DNA #Mitochondrial Function and Pathology #Mitochondrial apoptosis-induced channel #Mitochondrial intermembrane space #Mitochondrion #Mitophagy #PINK1 #Programmed cell death #Proteases #Rhomboid #mitochondrial fusion

paper · pdf · doi:10.1016/j.cell.2006.06.021

published in Cell 126(1), 163-175 (Elsevier BV)

crossref issued 2006/07/01 · crossref published 2006/07/01 · crossref published-print 2006/07/01 · openalex publication_date 2006/07/01 · crossref created 2006/07/21 · crossref deposited 2025/09/25 · openalex created_date 2025/10/10 · crossref indexed 2026/07/13 · openalex updated_date 2026/07/29

Citations

• A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis
• OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
• Dynamin-related Protein Drp1 Is Required for Mitochondrial Division in Mammalian Cells

Cited by

• OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
• Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency
• The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage
• Luca Scorrano [wikipedia]