A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

2002/01/01 by Luca Scorrano, Mona Ashiya, Karolyn Buttle +4 · 938 citations
Biochemistry, Genetics and Molecular Biology · #ATP Synthase and ATPases Research #Apoptosis #Biochemistry #Biology #Cell biology #Cell death mechanisms and regulation #Cytochrome #Cytochrome c #Enzyme #Genetics #Mitochondrial Function and Pathology #Mitochondrion

paper · pdf · doi:10.1016/s1534-5807(01)00116-2

published in Developmental Cell 2(1), 55-67 (Elsevier BV)

crossref issued 2002/01/01 · crossref published 2002/01/01 · crossref published-print 2002/01/01 · openalex publication_date 2002/01/01 · crossref created 2004/04/15 · openalex created_date 2025/10/10 · crossref deposited 2025/10/26 · crossref indexed 2026/08/05 · openalex updated_date 2026/08/06

Citations

• The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
• THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS

Cited by

• OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
• Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency
• Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
• The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage
• During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
• OPA1 requires mitofusin 1 to promote mitochondrial fusion
• Luca Scorrano [wikipedia]