2012/10/09 by Rúben Fernandes, Paula Amador, Cristina Prudêncio · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Antibiotic Resistance in Bacteria #Antibiotics Pharmacokinetics and Efficacy #Antimicrobial Resistance in Staphylococcus
paper · doi:10.1097/mrm.0b013e3283587727
openalex publication_date 2012/10/09 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/07
This synopsis summarizes the key chemical and bacteriological characteristics of β-lactams, penicillins, cephalosporins, carbanpenems, monobactams and others. Particular notice is given to first-generation to fifth-generation cephalosporins. This review also summarizes the main resistance mechanism to antibiotics, focusing particular attention to those conferring resistance to broad-spectrum cephalosporins by means of production of emerging cephalosporinases (extended-spectrum β-lactamases and AmpC β-lactamases), target alteration (penicillin-binding proteins from methicillin-resistant Staphylococcus aureus) and membrane transporters that pump β-lactams out of the bacterial cell.