2008/01/31 by André Zapun, Carlos Contreras‐Martel, Thierry Vernet · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Antibiotic Resistance in Bacteria #Antibiotic resistance #Antibiotics #Antibiotics Pharmacokinetics and Efficacy #Antimicrobial Resistance in Staphylococcus #Bacteria #Binding site #Biochemistry #Biology #DNA-binding protein #Endogeny #Gene #Genetics #Homologous recombination #Lipid II #Microbiology #Mutation #Penicillin #Penicillin binding proteins #Peptidoglycan #Point mutation #Transcription factor
paper · pdf · doi:10.1111/j.1574-6976.2007.00095.x
openalex publication_date 2008/01/31 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/04
A number of ways and means have evolved to provide resistance to eubacteria challenged by beta-lactams. This review is focused on pathogens that resist by expressing low-affinity targets for these antibiotics, the penicillin-binding proteins (PBPs). Even within this narrow focus, a great variety of strategies have been uncovered such as the acquisition of an additional low-affinity PBP, the overexpression of an endogenous low-affinity PBP, the alteration of endogenous PBPs by point mutations or homologous recombination or a combination of the above.